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Overview of chemogenetic tools indicating signaling pathway, activating compound, and neuronal effect
| DREADD | Activating ligand | Signaling pathway | Neuronal effect |
|---|---|---|---|
| hM3Dq | Clozapine-N-oxide | Gαq | Increased firing |
| hM4Di | Clozapine-N-oxide | Gαi | Decreased firing |
| rM3Ds | Clozapine-N-oxide | Gαs | Increased firing |
| Rq | Clozapine-N-oxide | β-arrestin | Specific β-arrestin signaling |
| KORD | Salvinorin B | Gαi | Decreased firing |
