Fig. 7.

HBXIP-elevated PKM2 contributes to accelerated cell proliferation in ER+ breast cancer. a, b Imaging (a) and growth curve (b) of the xenograft tumors derived from MCF-7 cells with indicated treatment (each group, n = 5). c Weight of the xenograft tumors derived from MCF-7 cells. d, e Statistics of Ki67 positive cells (d) and Ki67 staining by IHC assay (e) of the xenograft tumors derived from MCF-7 cells. The blank control group was treated with PBS instead of Ki67 antibody. Scale bar, 50 μm. Statistically significant differences are indicated: **P < 0.01, ***P < 0.001; all experiments were repeated at least three times