a Changes in BPRS total scores over time in first vs. second episodes (N = 130). The mixed-model analysis revealed a significant interaction between episode and time (F = 13.8, df = 15, 2242, P < 0.001). ***P < 0.001, **P < 0.01, *P < 0.05. BPRS brief psychiatric rating scale. b Changes in BPRS positive symptom scores over time in first vs. second episodes (N = 130). The mixed-model analysis revealed a significant interaction between episode and time (F = 20.5, df = 15, 2288, P < 0.0001). ***P < 0.001, **P < 0.01, *P < 0.05. BPRS brief psychiatric rating scale