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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Cancer Res. 2019 Jan 24;79(7):1343–1352. doi: 10.1158/0008-5472.CAN-18-2168

Figure 1.

Figure 1

Representative post-gadolinium image (A) with tumour rim (red) and core (green) regions of interest overlaid (B), and APTR* map (C) from preclinical model of brain metastasis. The contrast-enhancing tumour rim and hypo- to isointense tumour core resemble images obtained from human metastatic foci, and illustrate the intratumoural heterogeneity of an infiltrating rim region and necrotic core. Enhancement in the APTR* map in the region of the tumour is evident. No tumour burden in the contralateral hemisphere is apparent.