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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Cancer Res. 2019 Jan 24;79(7):1343–1352. doi: 10.1158/0008-5472.CAN-18-2168

Figure 7.

Figure 7

Histogram of APTR* values measured from tumours on mice treated with Atovaquone to decrease tumour hypoxia or with DMSO as control (A). The median APTR* was significantly lower in Atovaquone-treated animals (P < 0.001, Mann-Whitney test). The heterogeneity of APTR* values within single tumours is shown in representative animals from each group (B) to demonstrate the necessity of the histogram analysis. isoAPTR* analysis measured a tumour pH reduction of 0.07 pH units (C), consistent with the decrease in tumour pH expected with a reduction of tumour hypoxia.