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Structures of M2-BRIL and the S110R mutant bound to NMS. (a) Superposition of M2-BRIL (cyan) and S110R mutant (gray) bound to NMS. (b) R1103.39 and D692.50 of the S110R mutant form a salt bridge interaction. R1103.39 also interacts with S4437.46. Superposition of (c) M2-BRIL or the (d) S110R mutant bound to NMS with A2A receptor bound to ZM 241385 (PDB ID: 4EIY, blue).
