Table 2.
Mediation of Associations Between Measures of Adipositya on Risk of Colorectal Cancer by Inflammatory and Metabolic Biomarkers
| All Mediators | Inflammatory Mediatorsb | Metabolic Mediatorsc | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Body Mass Index (209 cases/382 controls)d | ||||||
| Total effect estimate | 1.40 | 1.13, 1.73 | 1.40 | 1.13, 1.73 | 1.40 | 1.13, 1.73 |
| Natural direct effect estimatee | 1.11 | 0.87, 1.42 | 1.34 | 1.07, 1.68 | 1.13 | 0.90, 1.41 |
| Natural indirect effect estimatef | 1.26 | 0.97, 1.52 | 1.05 | 0.96, 1.14 | 1.24 | 0.92, 1.55 |
| Adult Weight Gain (204 cases/369 controls)d,g | ||||||
| Total effect estimate | 1.32 | 1.06, 1.64 | 1.32 | 1.06, 1.64 | 1.32 | 1.06, 1.64 |
| Natural direct effect estimatee | 0.89 | 0.72, 1.11 | 1.23 | 0.97, 1.56 | 0.97 | 0.81, 1.16 |
| Natural indirect effect estimatef | 1.47 | 1.01, 1.81 | 1.07 | 0.93, 1.22 | 1.35 | 0.88, 1.90 |
| Waist Circumference (166 cases/318 controls)d | ||||||
| Total effect estimate | 1.71 | 1.30, 2.25 | 1.71 | 1.30, 2.25 | 1.71 | 1.30, 2.25 |
| Natural direct effect estimatee | 1.90 | 1.35, 2.66 | 1.77 | 1.31, 2.38 | 1.84 | 1.32, 2.57 |
| Natural indirect effect estimatef | 0.90 | 0.70, 1.16 | 0.97 | 0.89, 1.05 | 0.93 | 0.72, 1.18 |
Per one-unit increase in the interquartile range of each adiposity measure (body mass index: 3.6 kg/m2; adult weight gain: 10.4 kg; waist circumference: 11.4 cm)
Includes C-reactive protein, interleukin-6, tumor necrosis factor receptor 2, and macrophage inhibitory cytokine-1
Includes adiponectin, C-peptide, and soluble leptin receptor
Adjusted for age at blood draw (montds), time of blood draw (montd and year), energy intake (kcal/day, continuous), physical activity (MET-hrs/week, continuous), regular NSAID or aspirin use (<2 vs. ≥2 pills/week), family history of CRC (yes vs. no), red and processed meat intake (servings/day, continuous), total folate intake (mg/day), previous history of CRC screening (yes vs. no), smoking (packyears, continuous), regular multivitamin use (yes vs. no), supplemental calcium use (mg/day, continuous), alcohol intake (g/day, continuous), DASH score (continuous), and height (inches, continuous)
The estimated effect of the exposure on colorectal cancer risk that is not mediated by the biomarkers of interest.
The estimated effect of the exposure on colorectal cancer risk that is mediated by the biomarkers of interest.
Additionally adjusted for BMI at age 21 (kg/m2, continuous)