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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Curr Opin Cell Biol. 2019 Feb 1;57:90–98. doi: 10.1016/j.ceb.2018.12.012

Figure 1. An overview of SOCE choreography.

Figure 1.

In resting cells with high ER [Ca2+], STIM1 and Orai1 diffuse in the ER and PM, respectively (top). Upon ER Ca2+ depletion, STIM1 becomes activated and accumulates at ER-plasma membrane junctions to bind and trap Orai1 (middle). STIM1 binding opens Orai1 channels and allows extracellular Ca2+ to flow into the cell (bottom).