Table 3.
Relative mRNA expression of pre-pro-ET-1, ETA and ETB receptors, ER stress markers and toll-like receptors 2 and 4 in cortex of TG control and ETB-deficient rats after 3 weeks of high salt diet and daily treatment with vehicle or TUDCA. n = 6–9/group.
| CORTICAL mRNA EXPRESSION | ||||
|---|---|---|---|---|
| TG control + 8% NaCl | ETB-deficient + 8% NaCl | |||
| Vehicle | TUDCA | Vehicle | TUDCA | |
| Edn1 | 1.0 ± 0.3 | 1.1 ± 0.3 | 0.5 ± 0.2 | 0.7 ± 0.3 |
| Ednra | 1.0 ± 0.5 | 2.0 ± 0.7 | 0.7 ± 0.4 | 0.9 ± 0.5 |
| Ednrb | 1.0 ± 0.4 | 1.3 ± 0.4 | 1.0 ± 0.5 | 0.9 ± 0.4 |
| GRP78 | 1.0 ± 0.4 | 1.26 ± 0.2 | 1.8 ± 0.8 | 1.3 ± 0.4 |
| ATF-6 | 1.0 ± 0.4 | 1.5 ± 0.5 | 1.1 ± 0.5 | 1.3 ± 0.5 |
| ATF-4 | 1.0 ± 0.4 | 1.0 ± 0.4 | 1.1 ± 0.5 | 0.8 ± 0.3 |
| sXBP-1 | 1.0 ± 0.4 | 1.2 ± 0.3 | 1.2 ± 0.5 | 1.5 ± 0.7 |
| CHOP | 1.0 ± 0.3 | 1.4 ± 0.3 | 1.4 ± 0.4 | 1.9 ± 0.5 |
| Caspase-12 | 1.0 ± 0.4 | 0.9 ± 0.3 | 1.9 ± 1.1 | 1.2 ± 0.6 |
| Tlr2 | 1.0 ± 0.2 | 0.9 ± 0.2 | 1.7 ± 0.3 | 1.0 ± 0.2 |
| Tlr4 | 1.0 ± 0.2 | 1.2 ± 0.4 | 3.4 ± 1.2 | 1.9 ± 0.4 |