Effect of PAM3 on the function of lupus monocytes.
MACS purified monocytes were cultured as described in Fig 2. A) The uptake of zymosan-labelled particles after 5 days of culture (N= 17 lupus samples and 6 controls). B) Correlation between the expression of CD163 and uptake of zymosan particles. C) Concentration of TNFα in culture supernatants. D) Percent of cultured cells staining for intracytoplasmic IL-12. E) Concentration of IL-10 in culture supernatants (N = 12 lupus samples and controls).
** p<.01; *** p<.001; **** p<.0001 compared unstimulated cells from the same donors.