FIGURE 8.

LRP1 deletion in microglia prevents development of allodynia after sciatic nerve PNL. (a) TAM-treated Cx3cr1-CreER^T-LRP1^fl/fl mice (red curve) and Cx3cr1-CreER^T-LRP1 mice (black curve) were baseline tested with von Frey hairs for three days and then subjected to PNL. The mean baseline value for each group is presented at Day 0. PWTs were determined on the indicated days throughout 3 weeks (mean ± s.e.m; n = 9/group; *p < 0.05, **p < 0.01, ***p < 0.001 as compared with the corresponding basal PWTs; ^###p < 0.0001 as compared with control mice; repeated measures ANOVA with post-hoc Bonferroni’s test). (b) TAM-treated Cx3cr1-CreER^T-LRP1^fl/fl mice (red curve) and Cx3cr1-CreER^T-LRP1 mice (black curve) were baseline tested and then subjected to Rotarod-testing (mean ± s.e.m.; n = 5; p = 0.5, repeated measures ANOVA). Significant differences between the two genotypes were not observed.