Table 3.
Clinical and laboratory characteristics of SLE patients with the elevated and normal levels of serum anti-GAPDH antibodies.
| Clinical and laboratory parameters | Anti-GAPDH | t/u/χ 2 | P | |
|---|---|---|---|---|
| <55.09 (n = 44) | ≥55.09 (n = 86) | |||
| Rash | 21 (47.73%) | 34 (39.53%) | 0.800 | 0.371 |
| Nervous system | 11 (25.00%) | 24 (27.91%) | 0.125 | 0.835 |
| Hematological system | 26 (59.09%) | 59 (68.60%) | 1.164 | 0.281 |
| Joint involvement | 15 (34.09%) | 41 (47.67%) | 2.190 | 0.139 |
| Malar rash | 16 (36.36%) | 20 (23.26%) | 2.498 | 0.114 |
| Lung involvement | 6 (13.64%) | 17 (19.77%) | 0.751 | 0.386 |
| LN | 26 (59.09%) | 30 (34.88%) | 6.956 | 0.008 |
| WBC | 6.050 (4.20, 7.99) | 4.845 (3.56, 7.68) | -1.314 | 0.189 |
| HB | 108.79 ± 20.34 | 109.29 ± 20.64 | 0.132 | 0.895 |
| PLT | 178.76 ± 88.07 | 169.22 ± 85.59 | -0.595 | 0.553 |
| C3 | 0.62 ± 0.30 | 0.66 ± 0.30 | -0.725 | 0.470 |
| C4 | 0.13 (0.07, 0.17) | 0.12 (0.06, 0.20) | -0.189 | 0.850 |
| IgA | 2.40 (1.58, 3.73) | 2.57 (1.89, 3.87) | -0.688 | 0.491 |
| IgG | 12.85 (9.33, 17.73) | 17.10 (13.10, 20.05) | -0.278 | 0.006 |
| IgM | 0.84 (0.51, 1.23) | 1.02 (0.72, 1.49) | -2.390 | 0.017 |
| RF | 7 (16.67%) | 23 (27.06%) | 1.683 | 0.267 |
| CRP | 2.75 (1.41, 9.28) | 6.65 (2.23, 13.80) | -2.197 | 0.028 |
| ESR | 21.00 (13.00, 40.00) | 35.00 (21.00, 65.50) | -3.172 | 0.002 |
| Acl | 4.45 (1.73, 11.90) | 5.00 (2.10, 10.95) | -0.412 | 0.680 |
| β2-GI | 3.84 (2.00, 15.87) | 5.47 (2.00, 16.63) | -0.618 | 0.537 |
| Anti-dsDNA | 28.20 (5.80, 153.20) | 51.80 (13.50, 200.00) | -1.670 | 0.095 |
| AnuA | 36.07 (5.69, 147.84) | 31.45 (7.37, 191.90) | -0.840 | 0.401 |
| ANA ≥ 1 : 320 | 35 (79.55%) | 75 (87.21%) | 0.772 | 0.380 |
| Anti-SSA | 23 (54.76%) | 46 (53.49%) | 0.018 | 0.892 |
| Anti-SSB | 5 (11.90%) | 10 (11.63%) | 0.002 | 1.000 |
| Urine protein | 21 (47.73%) | 28 (33.33%) | 2.532 | 0.112 |
| SLEDAI-2K ≥ 10 | 24 (54.55%) | 60 (69.77%) | 2.950 | 0.086 |
LN: lupus nephritis; WBC: white blood cell; HB: hemoglobin; PLT: platelet count; C3: complement component 3; C4: complement component 4; IgA: immunoglobulin A; IgG: immunoglobulin G; IgM: immunoglobulin M; RF: rheumatoid factor; CRP: C-reaction protein; ESR: erythrocyte sedimentation rate; Acl: anti-cardiolipin; β2-GPI: anti-β2 glycoprotein I Abs; anti-dsDNA: anti-double-stranded DNA antibodies; AnuA: anti-nucleosome antibodies; ANA: anti-nuclear antibodies; anti-SSA: anti-SSA antibody; anti-SSB: anti-SSB antibody; SLEDAI-2K: systemic lupus erythematosus disease activity index 2000.