Table 2.

Correlation between FOLR1, DHFR, and MTRR expression and clinicopathological parameters.

Parameters		Total	FOLR expression	P	DHFR expression	P	MTRR expression	P
Histology	Epithelial	61	4.979 ± 2.326	0.001	0.234 ± 0.227	0.543	0.872 ± 0.752	0.001
	Other	19	8.682 ± 2.501		0.271 ± 0.261		1.528 ± 0.697
FIGO Stage	I-II	37	4.982 ± 2.746	0.004	0.270 ± .2761	0.360	0.854 ± 0.459	0.036
	III-IV	43	6.785 ± 2.740		0.221 ± 0.194		1.207 ± 0.965
Grade	G1	30	4.835 ± 2.867	0.006	0.191 ± 0.132	0.123	0.802 ± 0.300	0.033
	G2-G3	50	6.621 ± 2.685		0.275 ± 0.276		1.189 ± 0.945
Node status	Positive	23	4.834 ± 3.000	0.026	0.184 ± 0.140	0.149	1.317 ± 1.012	0.048
	Negative	57	6.402 ± 2.716		0.268 ± 0.261		0.933 ± 0.657
Omentum metastasis	Yes	28	6.193 ± 2.712	0.584	0.172 ± 0.162	0.044	1.003 ± 0.595	0.734
	No	52	5.821 ± 2.971		0.283 ± 0.260		1.066 ± 0.880
Organ metastasis∗	Yes	20	7.286 ± 2.397	0.015	0.181 ± 0.179	0.169	1.475 ± 1.072	0.032
	No	60	5.506 ± 2.896		0.265 ± 0.249		0.900 ± 0.616
Ascites	≥500 ml	30	6.327 ± 2.697	0.367	0.186 ± 0.164	0.087	1.203 ± 1.047	0.227
	<500 ml	50	5.725 ± 2.975		0.279 ± 0.265		0.948 ± 0.574
Platinum resistance	Resistant	28	4.804 ± 2.262	0.004	0.331 ± 0.295	0.014	1.333 ± 1.026	0.015
	Sensitive	52	6.569 ± 2.991		0.197 ± 0.183		0.888 ± 0.579
Outcome	CR	27	7.272 ± 3.402	0.001	0.170 ± 0.085	0.032	0.793 ± 0.645	0.047
	PR	25	6.421 ± 2.434		0.224 ± 0.142		0.957 ± 0.630
	SD	12	4.720 ± 1.960		0.268 ± 0.251		1.291 ± 0.546
	PD	16	3.913 ± 1.384		0.383 ± 0.411		1.418 ± 1.174

Notes: ^∗: metastasis to any one of liver, lung, brain and spleen.