Table 5.
Univariate and multivariate analysis of survival in 80 patients with OC.
| Variables | Univariate analysis | Multivariate analysisa | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Histology | ||||||
| Epithelial vs. other | 1.690 | 0.798-3.852 | 0.171 | — | — | — |
| FIGO Stage | ||||||
| I-II vs. III-IV | 2.349 | 1.143-4.826 | 0.020 | 1.004 | 0.319-3.164 | 0.994 |
| Grade | ||||||
| G1 vs. G2-G3 | 2.491 | 1.183-5.244 | 0.016 | 2.529 | 0.755-8.472 | 0.133 |
| Node status | ||||||
| Positive vs. negative | 1.700 | 0.816-3.540 | 0.156 | — | — | — |
| Omentum metastasis | ||||||
| Positive vs. negative | 0.868 | 0.428-1.761 | 0.695 | — | — | — |
| Organ metastasis∗ | ||||||
| Positive vs. negative | 1.168 | 0.560- 2.438 | 0.678 | — | — | — |
| Ascites | ||||||
| ≥500 ml vs. <500 ml | 2.175 | 1.072-4.411 | 0.031 | 1.715 | 0.489-6.016 | 0.400 |
| Platinum resistance | ||||||
| Resistant vs. sensitive | 2.675 | 1.263-5.663 | 0.010 | 1.861 | 0.510-6.787 | 0.347 |
| FOLR1-positive expression alone | ||||||
| Positive vs. negative | 0.824 | 0.394-1.721 | 0.606 | — | — | — |
| DHFR-positive expression alone | ||||||
| Positive vs. negative | 1.410 | 0.720-2.761 | 0.316 | — | — | — |
| MTRR-positive expression alone | ||||||
| Positive vs. negative | 2.334 | 1.066-5.110 | 0.034 | 1.444 | 0.607-3.432 | 0.406 |
Notes: aBackward Wald test was used for variables screened. P < 0.05 was chosen as a criterion for significance. HR: hazard ratio; CI: 95% confidence interval. ∗Metastasis to any one of liver, lung, brain, and spleen.