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. 2019 Apr 10;39(15):2965–2975. doi: 10.1523/JNEUROSCI.1728-18.2018

Figure 6.

Figure 6.

Increased M2 input in central striatum is accompanied by increased NMDA currents. A, B, After recording M2 light-evoked AMPA-mediated currents at Vhold = −80 mV, cells were held at Vhold = 40 mV to record NMDA-mediated currents. Amplitude of NMDA-mediated current was measured 60 ms after the peak of the response, at which time the AMPA-mediated portion of the current has decayed. Gray represents WT. Pink represents KO. C, AMPA/NMDA ratios in SPNs were significantly lower in KOs relative to WTs (WT 4.09 ± 4.36, KO 1.94, IQR = 2.22; Z = 3.29, p = 9.89 × 10−4, WRST). D, AMPA/NMDA ratios were not significantly different between genotypes in FSIs (WT 16.67, IQR = 14.28, KO 11.79, IQR = 14.14; Z = 0.86, p = 0.39, WRST). E, F, Examples of isolated NMDA responses with pharmacological block of AMPA receptors with 5 μm DNQX. Gray represents WT. Pink represents KO. G, NMDA-mediated currents were significantly greater in SPNs in KO mice (174.77, IQR = 268.43 pA, 3 mice, 18 cells) relative to WTs (95.99 pA, IQR = 111.69 pA, 5 mice, 19 cells; Z = −2.23, p = 0.02, WRST). H, NMDA-mediated currents were significantly greater in FSIs in KO mice (108.61 pA, IQR = 79.91 pA, 3 mice, 16 cells) relative to WT mice (27.56, IQR = 75.81 pA, 4 mice, 11 cells; Z = −2.25, p = 0.02, WRST).