Skip to main content
. 2019 Apr 10;39(15):2951–2964. doi: 10.1523/JNEUROSCI.1384-18.2019

Figure 6.

Figure 6.

Genetic inhibition of RIPK3-mediated necroptosis and Caspase-8-mediated apoptosis alleviates cisplatin ototoxicity in vivo. A, Schematic illustration of the cisplatin/furosemide combination ototoxicity paradigm in mutant mice. B, Auditory thresholds increased ∼40–50 dB compared with pre-exposure in WT mice. C, Auditory thresholds increased ∼15–20 dB compared with pre-exposure in Ripk3 KO mice. D, Auditory thresholds increased ∼10 dB compared with pre-exposure in Casp8/Ripk3 DOKO mice. E, Degree of threshold shift at each frequency for each genotype. Error bars indicate the SD. Statistical significance: ****p < 0.00001. Number of animals (n) per group: WT (n = 10); Ripk3 KO (n = 8, 5 females, 3 males); and Casp8/Ripk3 DOKO (n = 10, 7 females, 3 males). See Table 6-1.