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. 2018 Sep 4;294(14):5408–5419. doi: 10.1074/jbc.TM118.000831

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© 2019 Tran et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 3. — A, HIF1 recruits Kdm3a under hypoxic conditions, regulating gene expression by the removal of H3K9me2. B, Kdm2b binds unmethylated CpG islands via a ZF-CXXC domain. Kdm2b is part of the PRC1.1 complex that mediates gene repression through the ubiquitination (Ub) of histone H2A. C, the Kdm4 family of proteins reduce the levels of H3K9me3 at reprogramming-resistant regions, opening the condensed heterochromatin and allowing transcription. D, Kdm5a interacts with the PRC2 complex, removing H3K4me at bivalent genes, leading to gene repression.