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. 2019 Feb 8;294(14):5521–5535. doi: 10.1074/jbc.RA118.004340

Figure 2.

Figure 2.

AKAP79 promotes the expression of homomeric GluA1 CP-AMPARs. HEK 293 cells were transfected with GluA1/GluA2 with or without AKAP79. A, individual I-V relationships for cells expressing GluA1/GluA2 with or without AKAP79-GFP. Data are normalized to the current at −60 mV. B, averaged data for sweeps in A. C, representative experiment demonstrating that the inwardly rectifying component in AKAP79-expressing cells is completely blocked by the CP-AMPAR blocker 1-naphthylacetylspermine (NASPM). D, summary graph of initial current density measured at −60 and +40 mV obtained from a ramp protocol. Individual cells for each condition are shown. Open symbols, cells in which PKM was included in the pipette solution; filled symbols, cells in which PKM was not included. *, p < 0.05, compared with GluA1/GluA2. Error bars, S.E.