Figure 2.

Prevalent characteristics of CMT-linked aaRSs. Prevalence rate is calculated as a ratio between the number of CMT-linked aaRSs and the total number of aaRSs within a certain category. Class I aaRSs include VARS, IARS, LARS, MARS, CARS, RARS, EARS, QARS, YARS, and WARS, and class II includes SARS, TARS, PARS, GARS, HARS, AARS, DARS, NARS, KARS, and FARS. The monomeric aaRSs are class I aaRSs except for YARS and WARS, which are dimers. Class II aaRSs are dimeric. FARS are tetrameric, which can be considered as a dimer of dimer. The MSC contains IARS, LARS, MARS, RARS, QARS KARS, DARS, EPRS/GluProRS, and three nonenzymatic factors. The WHEP domain–containing aaRSs include GARS, HARS, WARS, MARS, and EPRS.