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. 2019 Jan 22;294(14):5365–5385. doi: 10.1074/jbc.REV118.002956

Figure 1.

Figure 1.

Aminoacylation reaction and the two classes of aminoacyl-tRNA synthetases. A, two half-reactions of the aminoacylation reaction, showing structures of the reactants and products. For most tRNA synthetases, the amino acid activation reaction can occur in the absence of tRNA. In the case of glutamyl-tRNA synthetase (GluRS), glutaminyl-tRNA synthetase (GlnRS), and arginyl-tRNA synthetase (ArgRS), the presence of tRNA is required for amino acid activation. B, representative structures of each of the 20 standard ARSs, divided into the two principal structural classes. The RCSB Protein Data Bank ID numbers are indicated below each structure.