Figure 3.

X-ray structures of selected ARS–inhibitor complexes. In each case, the secondary structure of polypeptide chain is depicted in ribbon representation (green), and the inhibitors are depicted in stick representation (blue or yellow). Selected active-site residues are shown in each panel, including the conserved motif 2 arginine. A, complex of P. falciparum LysRS with lysine and cladosporin (cyan) (PDB code 4YDQ). B, complex of HF with Homo sapiens ProRS (PDB code 4HVC). C, complex of H. sapiens ThrRS and borrelidin (PDB code 4P3N); D, complex of E. coli IleRS with mupirocin (PDB code 1JZS).