Table 1. Gene ontology analysis of up- and down-regulated DEGs associated with ccRCC.
| Expression | Category | Term | Count | P value |
|---|---|---|---|---|
| Up-regulation | GOTERM_BP_FAT | GO:0006955~immune response | 34 | 2.46E-14 |
| GOTERM_BP_FAT | GO:0009611~response to wounding | 24 | 2.39E-09 | |
| GOTERM_BP_FAT | GO:0006954~inflammatory response | 18 | 2.42E-08 | |
| GOTERM_BP_FAT | GO:0001666~response to hypoxia | 12 | 9.39E-08 | |
| GOTERM_BP_FAT | GO:0070482~response to oxygen levels | 12 | 1.58E-07 | |
| GOTERM_CC_FAT | GO:0005576~extracellular region | 51 | 8.39E-09 | |
| GOTERM_CC_FAT | GO:0005615~extracellular space | 27 | 3.05E-08 | |
| GOTERM_CC_FAT | GO:0044421~extracellular region part | 32 | 4.93E-08 | |
| GOTERM_CC_FAT | GO:0031262~Ndc80 complex | 3 | 7.25E-04 | |
| GOTERM_CC_FAT | GO:0005625~soluble fraction | 11 | 2.58E-03 | |
| GOTERM_MF_FAT | GO:0005125~cytokine activity | 11 | 1.03E-05 | |
| GOTERM_MF_FAT | GO:0008009~chemokine activity | 6 | 5.57E-05 | |
| GOTERM_MF_FAT | GO:0042379~chemokine receptor binding | 6 | 7.58E-05 | |
| GOTERM_MF_FAT | GO:0042803~protein homodimerization activity | 12 | 2.12E-04 | |
| GOTERM_MF_FAT | GO:0042802~identical protein binding | 16 | 6.18E-04 | |
| Down-regulation | GOTERM_BP_FAT | GO:0006811~ion transport | 38 | 1.42E-10 |
| GOTERM_BP_FAT | GO:0006820~anion transport | 16 | 3.03E-09 | |
| GOTERM_BP_FAT | GO:0015672~monovalent inorganic cation transport | 21 | 5.14E-08 | |
| GOTERM_BP_FAT | GO:0007588~excretion | 10 | 1.60E-07 | |
| GOTERM_BP_FAT | GO:0006812~cation transport | 26 | 6.31E-07 | |
| GOTERM_CC_FAT | GO:0045177~apical part of cell | 16 | 2.53E-07 | |
| GOTERM_CC_FAT | GO:0016324~apical plasma membrane | 14 | 2.77E-07 | |
| GOTERM_CC_FAT | GO:0005903~brush border | 8 | 9.08E-06 | |
| GOTERM_CC_FAT | GO:0005624~membrane fraction | 29 | 1.44E-04 | |
| GOTERM_CC_FAT | GO:0000267~cell fraction | 35 | 1.77E-04 | |
| GOTERM_MF_FAT | GO:0008509~anion transmembrane transporter activity | 16 | 2.63E-09 | |
| GOTERM_MF_FAT | GO:0031402~sodium ion binding | 12 | 8.54E-07 | |
| GOTERM_MF_FAT | GO:0031420~alkali metal ion binding | 16 | 9.09E-07 | |
| GOTERM_MF_FAT | GO:0015293~symporter activity | 11 | 2.60E-05 | |
| GOTERM_MF_FAT | GO:0048037~cofactor binding | 14 | 5.79E-05 |
DEG, differentially expressed gene; ccRCC, clear cell renal cell carcinoma.