Table 2. Signaling pathway enrichment analysis of differentially expressed genes associated with ccRCC.
| Pathway ID | Name | Count | P value | Gene |
|---|---|---|---|---|
| Up-regulated DEGs | ||||
| hsa04060 | Cytokine-cytokine receptor interaction | 15 | 3.50E-07 | VEGFA, CXCR4, INHBB, NFSF9, CCL28, IL10RA, CD70, CCR5, TNFSF13B, CCL5, CCL4, CCL18, CXCL13, IL20RB, CCL20 |
| hsa05150 | Staphylococcus aureus infection | 6 | 4.05E-05 | C1QA, C1QB, C1QC, CDF, FPR3, C3 |
| hsa05020 | Prion diseases | 4 | 0.000659 | C1QA, C1QB, C1QC, CCL5 |
| hsa05142 | Chagas disease | 6 | 0.0011 | C1QA, C1QB, C1QC, CCL5, C3, CD247 |
| hsa04062 | Chemokine signaling pathway | 8 | 0.001257 | CXCR4, CCL28, CCR5, CCL5, CCL4, CCL18, CXCL13, CCL20 |
| hsa03320 | PPAR signaling pathway | 5 | 0.001388 | ANGPTL4, FABP5, FABP7, SCD, CD36, |
| hsa04610 | Complement and coagulation cascades | 5 | 0.0021 | C1QA, C1QB, C1QC, CFD, C3 |
| hsa04672 | Intestinal immune network for IgA production | 4 | 0.002359 | CD86, CXCR4, CCL28, TNSF13B |
| Down-regulated DEGs | ||||
| hsa04966 | Collecting duct acid secretion | 6 | 4.36E-06 | ATP6V1G3, ATP6V0D2, ATP6V0A4, CLCNKB, ATP6V1C2, SLC4A1 |
| hsa00350 | Tyrosine metabolism | 6 | 2.14E-05 | TYRP1, HPD, ADH1C, ADH1B, ADH6, DDC |
| hsa04960 | Aldosterone-regulated sodium reabsorption | 6 | 2.99E-05 | SCNN1G, FXYD4, KCNJ1, HSD11B2, SCNN1B, NR3C2 |
| hsa00010 | Glycolysis/Gluconeogenesis | 7 | 0.000119 | ADH1C, ALDOB, ADH1B, G6PC, ADH6, FBP1, PCK1 |
| hsa00260 | Glycine, serine and threonine metabolism | 5 | 0.000502 | DAO, GLDC, PIPOX, AGXT2, PSAT1 |
DEG, differentially expressed gene; ccRCC, clear cell renal cell carcinoma.