. 2019 Mar;7(5):89. doi: 10.21037/atm.2019.01.18

Table S1. Two hundred and four DEGs were filtered from the datasets, including 52 up-regulated genes and 152 down-regulated genes in ccRCC samples compared to normal samples.

DEGs	Gene name
Up-regulated	IGFBP3, ANGPTL4, FUT11, ENO2, HILPDA, TMEM91, CAV1, CAV2, ANGPT2, VIM, FABP5, MIR210HG, LPCAT1, NOL3, APOBEC3C, NDUFA4L2, PLA2G7, FAM49A, HK1, CDCA2, TNFAIP6, VEGFA, IRX3, PYGL, DDB2, ANXA2R, GJC1, ENTPD1, IFI16, SPAG4, ZNF395, EGLN3, CD86, SEMA5B, CXCR4, PAG1, KIAA0101, INHBB, RNASE2, COL23A1, PLOD2, LGALS1, DIRAS2, ST8SIA4, CHSY3, IGSF6, LAPTM5, ADM, LDLRAD3, DGCR5, SLFN13, RAD51AP1, CD247, LINC00887, NETO2, C1QB, CRNDE, FCER1G, STC2, TNFSF9, CD300LF, CA9, CDH13, HEY1, LHFPL2, SLFN11, CDCA7L, CCND1, LINC01094, TYROBP, CFD, TMEM45A, HIST1H2BK, SPC25, NPTX2, CCL28, RASSF2, CTSS, C10orf10, IL10RA, SCD, PGBD5, OLFML2B, GAS2L3, DTL, DDIT4, C1QC, PSMB9, C1QA, FCGR1B, KIF14, FPR3, BIRC3, MS4A7, PRKCDBP, PPP1R3C, HAPLN1, KCNJ2, HCLS1, MAP3K7CL, PRC1, LOC100132891, TOP2A, IDO1, APOLD1, CLEC5A, KISS1R, DUSP5P1, CD70, LOC101927972, C3, ALDOC, LAMP3, CD36, EVI2B, CENPK, CEP55, NKG7, TRIB3, GBP5, CSTA, PLK2, NDC80, GZMA, ERV3-2, CCR5, CPE, TGFBI, APOC1, GBP2, CST7, NUF2, ANLN, GZMB, NMB, CRTAM, SLC2A3, UBE2C, CD163, CTHRC1, TNFSF13B, GAL3ST1, FABP7, QRFPR, DLGAP5, BCL2A1, RRM2, FKBP10, TREM1, LOX, VCAN, PLVAP, TEX11, CCL5, CP, CCL4, ABCA17P, KIF20A, ADAMDEC1, PRIMA1, RAB42, CCL18, C5orf46, PTHLH, UHRF1, ENPP3, LPPR5, LYZ, C19orf33, COL21A1, SPINK13, SORCS3, NEFL, LOC102659288, CYP2J2, C10orf99, LINC01127, CXCL13, IL20RB, CCL20
Down-regulated	CALB1, UMOD, NPHS2, HEPACAM2, LOC101929040, ATP6V1G3, DMRT2, SLC12A1, CA10, FGF1, SCNN1G, LPPR1, ATP6V0D2, RALYL, FXYD4, KNG1, TYRP1, SLC26A7, LINC01187, PTH1R, SFRP1, FAM3B, ANGPTL1, STAP1, KLK7, NPHS1, CLDN8, LOC100507537, SOST, SYNE4, CRHBP, MUC15, CWH43, HRG, ATP6V0A4, SMIM5, PIK3C2G, TMEM213, NRK, ACPP, TCEAL2, PLCXD3, FGF9, GPC5, DIO1, DDX25, LINC00645, IYD, TUBAL3, CLCNKB, TFAP2B, LOC100130278, GGT6, HS6ST2, AQP2, GRHL2, FOXI1, KCNJ1, ATP6V1C2, ENPP6, SERPINA5, SLC5A2, HYKK, PCDH9, RANBP3L, KLK6, IRX1, FLJ22763, SLC4A9, CRISP2, TMEM52B, DDN, LRRC2, XPNPEP2, C1orf168, TNNC1, ERP27, MRAP2, SLC13A2, SCN2A, LINC00551, LOC284578, ANO5, CCDC160, LOC101928303, SLC34A1, KCNJ10, SLC4A1, TCF21, ANGPTL3, SLC13A3, PACRG, RASSF10, SOWAHA, SLC30A2, HPD, ACSF2, CEL, C7, SLC7A8, PRLR, DACH1, SLC26A4, DUSP9, ADH1C, PPAPDC1A, FABP1, SLC47A2, SLC22A8, SHISA3, ALDOB, FAM169A, PLG, MTTP, TMEM45B, RBM11, CDH9, PTPRO, TSPAN8, SLIT2, DNMT3L, ERVMER34-1, ALB, SH3GL2, CRYAA, AFM, FAM151A, SOSTDC1, LOC149703, TMEM207, SLC12A3, DPEP1, BMPR1B, LOC101929480, LOC100130691, S100A2, GABRA2, CYP27B1, REEP6, RAB25, CPN2, GATA3, DAO, KCNMB2, TFCP2L1, MAN1C1, TMEM72, SMCO3, SFXN2, CNTN3, RHCG, HSD11B2, EFHD1, RNF212B, ABAT, IGSF11, PROC, SLC51B, HPGD, MAL, DCXR, CORO2B, GPR110, ESRP1, SCNN1B, UPP2, EGF, LINC00948, KCNJ13, OTOGL, ASS1, WNK4, FCAMR, ADH1B, PVALB, PCP4, GSTM3, SHISA2, TMEM178A, APELA, OGDHL, AGPAT9, SLC7A13, PTGDS, ESRRG, VTCN1, LOC727944, C16orf89, ALDH6A1, LOC389332, LOC101927244, SUCNR1, CDKN1C, CTXN3, UNC5D, CYP4F2, CHL1, G6PC, PIGR, ADH6, RGS7, SPINK1, SLC6A19, TAC1, LINC00473, CHRDL1, SLC16A10, OLFM4, TREH, ERICH4, LOC101928047, GLDC, CLSTN2, ETNPPL, FBLN5, TRIM71, ACOX2, CYP24A1, TUBB2B, FLJ35700, DCN, SLC14A1, KCNJ15, NAPSA, PRODH2, TRIM63, BEX1, SLC22A6, CHGB, NR3C2, BCHE, SLC22A12, BRE-AS1, C2orf40, LOC100505985, DEFB1, HSPA2, SCIN, FBP1, CYP8B1, LUM, HAO2, CA4, MIOX, DIRAS3, HOGA1, NDNF, LINC00113, ABCB1, CAPN3, AGR3, AZGP1, PIPOX, DNER, CKMT2, PRR15L, PCK1, TSPAN1, AGR2, PRAP1, SLC13A1, FREM2, ANXA3, MME, CYP4A11, TOX3, SLC17A1, SLC5A12, UGT3A1, CYP4F3, TINAG, GAS2, MEST, LRRC19, SLC16A9, MAL2, KL, PPP1R1A, DDC, GLYAT, AGXT2, PSAT1, LTF, MYH8, SLC27A2, FMO1, PROM1, ALDH8A1

DEGs

Gene name

Up-regulated

IGFBP3, ANGPTL4, FUT11, ENO2, HILPDA, TMEM91, CAV1, CAV2, ANGPT2, VIM, FABP5, MIR210HG, LPCAT1, NOL3, APOBEC3C, NDUFA4L2, PLA2G7, FAM49A, HK1, CDCA2, TNFAIP6, VEGFA, IRX3, PYGL, DDB2, ANXA2R, GJC1, ENTPD1, IFI16, SPAG4, ZNF395, EGLN3, CD86, SEMA5B, CXCR4, PAG1, KIAA0101, INHBB, RNASE2, COL23A1, PLOD2, LGALS1, DIRAS2, ST8SIA4, CHSY3, IGSF6, LAPTM5, ADM, LDLRAD3, DGCR5, SLFN13, RAD51AP1, CD247, LINC00887, NETO2, C1QB, CRNDE, FCER1G, STC2, TNFSF9, CD300LF, CA9, CDH13, HEY1, LHFPL2, SLFN11, CDCA7L, CCND1, LINC01094, TYROBP, CFD, TMEM45A, HIST1H2BK, SPC25, NPTX2, CCL28, RASSF2, CTSS, C10orf10, IL10RA, SCD, PGBD5, OLFML2B, GAS2L3, DTL, DDIT4, C1QC, PSMB9, C1QA, FCGR1B, KIF14, FPR3, BIRC3, MS4A7, PRKCDBP, PPP1R3C, HAPLN1, KCNJ2, HCLS1, MAP3K7CL, PRC1, LOC100132891, TOP2A, IDO1, APOLD1, CLEC5A, KISS1R, DUSP5P1, CD70, LOC101927972, C3, ALDOC, LAMP3, CD36, EVI2B, CENPK, CEP55, NKG7, TRIB3, GBP5, CSTA, PLK2, NDC80, GZMA, ERV3-2, CCR5, CPE, TGFBI, APOC1, GBP2, CST7, NUF2, ANLN, GZMB, NMB, CRTAM, SLC2A3, UBE2C, CD163, CTHRC1, TNFSF13B, GAL3ST1, FABP7, QRFPR, DLGAP5, BCL2A1, RRM2, FKBP10, TREM1, LOX, VCAN, PLVAP, TEX11, CCL5, CP, CCL4, ABCA17P, KIF20A, ADAMDEC1, PRIMA1, RAB42, CCL18, C5orf46, PTHLH, UHRF1, ENPP3, LPPR5, LYZ, C19orf33, COL21A1, SPINK13, SORCS3, NEFL, LOC102659288, CYP2J2, C10orf99, LINC01127, CXCL13, IL20RB, CCL20

Down-regulated

CALB1, UMOD, NPHS2, HEPACAM2, LOC101929040, ATP6V1G3, DMRT2, SLC12A1, CA10, FGF1, SCNN1G, LPPR1, ATP6V0D2, RALYL, FXYD4, KNG1, TYRP1, SLC26A7, LINC01187, PTH1R, SFRP1, FAM3B, ANGPTL1, STAP1, KLK7, NPHS1, CLDN8, LOC100507537, SOST, SYNE4, CRHBP, MUC15, CWH43, HRG, ATP6V0A4, SMIM5, PIK3C2G, TMEM213, NRK, ACPP, TCEAL2, PLCXD3, FGF9, GPC5, DIO1, DDX25, LINC00645, IYD, TUBAL3, CLCNKB, TFAP2B, LOC100130278, GGT6, HS6ST2, AQP2, GRHL2, FOXI1, KCNJ1, ATP6V1C2, ENPP6, SERPINA5, SLC5A2, HYKK, PCDH9, RANBP3L, KLK6, IRX1, FLJ22763, SLC4A9, CRISP2, TMEM52B, DDN, LRRC2, XPNPEP2, C1orf168, TNNC1, ERP27, MRAP2, SLC13A2, SCN2A, LINC00551, LOC284578, ANO5, CCDC160, LOC101928303, SLC34A1, KCNJ10, SLC4A1, TCF21, ANGPTL3, SLC13A3, PACRG, RASSF10, SOWAHA, SLC30A2, HPD, ACSF2, CEL, C7, SLC7A8, PRLR, DACH1, SLC26A4, DUSP9, ADH1C, PPAPDC1A, FABP1, SLC47A2, SLC22A8, SHISA3, ALDOB, FAM169A, PLG, MTTP, TMEM45B, RBM11, CDH9, PTPRO, TSPAN8, SLIT2, DNMT3L, ERVMER34-1, ALB, SH3GL2, CRYAA, AFM, FAM151A, SOSTDC1, LOC149703, TMEM207, SLC12A3, DPEP1, BMPR1B, LOC101929480, LOC100130691, S100A2, GABRA2, CYP27B1, REEP6, RAB25, CPN2, GATA3, DAO, KCNMB2, TFCP2L1, MAN1C1, TMEM72, SMCO3, SFXN2, CNTN3, RHCG, HSD11B2, EFHD1, RNF212B, ABAT, IGSF11, PROC, SLC51B, HPGD, MAL, DCXR, CORO2B, GPR110, ESRP1, SCNN1B, UPP2, EGF, LINC00948, KCNJ13, OTOGL, ASS1, WNK4, FCAMR, ADH1B, PVALB, PCP4, GSTM3, SHISA2, TMEM178A, APELA, OGDHL, AGPAT9, SLC7A13, PTGDS, ESRRG, VTCN1, LOC727944, C16orf89, ALDH6A1, LOC389332, LOC101927244, SUCNR1, CDKN1C, CTXN3, UNC5D, CYP4F2, CHL1, G6PC, PIGR, ADH6, RGS7, SPINK1, SLC6A19, TAC1, LINC00473, CHRDL1, SLC16A10, OLFM4, TREH, ERICH4, LOC101928047, GLDC, CLSTN2, ETNPPL, FBLN5, TRIM71, ACOX2, CYP24A1, TUBB2B, FLJ35700, DCN, SLC14A1, KCNJ15, NAPSA, PRODH2, TRIM63, BEX1, SLC22A6, CHGB, NR3C2, BCHE, SLC22A12, BRE-AS1, C2orf40, LOC100505985, DEFB1, HSPA2, SCIN, FBP1, CYP8B1, LUM, HAO2, CA4, MIOX, DIRAS3, HOGA1, NDNF, LINC00113, ABCB1, CAPN3, AGR3, AZGP1, PIPOX, DNER, CKMT2, PRR15L, PCK1, TSPAN1, AGR2, PRAP1, SLC13A1, FREM2, ANXA3, MME, CYP4A11, TOX3, SLC17A1, SLC5A12, UGT3A1, CYP4F3, TINAG, GAS2, MEST, LRRC19, SLC16A9, MAL2, KL, PPP1R1A, DDC, GLYAT, AGXT2, PSAT1, LTF, MYH8, SLC27A2, FMO1, PROM1, ALDH8A1

DEG, differentially expressed gene; ccRCC, clear cell renal cell carcinoma.