Table 1. Characteristics of including studies.
Study | Inclusion period | median follow-up, m [range] | Multi-center | Study arms | Patients (n) | Median, age, years, [range] | Gender, M:F | Staging criteria | Stage I/II/III/IV |
---|---|---|---|---|---|---|---|---|---|
Cao et al. 2017 | 2008.6–2015.2 | 50 [3–94] | Yes | PF + CCRT; CCRT alone | 238; 238 | 44 [19–65]; 42 [21–66] | 173:65; 190:48 | AJCC/UICC 6th edition | 0/1/117/120; 0/0/133/105 |
Sun et al. 2016 | 2011.3–2013.8 | 45 [39–49] | Yes | TPF + CCRT; CCRT alone | 241; 239 | 42 [36–49]; 44 [39–50] | 193:48; 174:65 | AJCC/UICC 7th edition | 0/0/129/112; 0/0/133/106 |
Jin et al. 2016 | 2012.4–2014.4 | 36 [24–48] | Yes | TPF + CCRT; PF + CCRT | 138; 138 | 48 [18–68]; 50 [25–69] | 99:39; 98:40 | AJCC/UICC 7th edition | 0/0/86/52; 0/0/94/64 |
Huang et al. 2013 | 2010.1–2010.6 | 20 [13–29] | No | TP + CCRT; PF + CCRT | 40; 40 | 42 [18–63]; 44 [19–66] | 28:12; 31:9 | AJCC/UICC 6th edition | 0/0/13/27; 0/0/17/23 |
Hui et al. 2009 | 2002.11–2004.11 | 51 | Yes | TP + CCRT; CCRT alone | 34; 31 | 50 [31–70]; 45 [32–70] | 21:13; 24:7 | AJCC/UICC 5th edition | 0/0/19/15; 0/0/19/12 |
Frikha et al. 2017 | 2009–2012 | 43.1 | Yes | TPF + CCRT; CCRT alone | 40; 41 | 46; 48 | 28:12; 32:9 | AJCC/UICC 6th edition | NA |
Gao et al. 2013 | 2008.5–2009.6 | 42† | No | PF + CCRT; CCRT alone | 57; 55 | [18–60] | 43:14; 39:16 | Fuzhou 1992 | 0/0/14/43; 0/0/11/44 |
†, all patients follow-up over 3 years. N, number; M, male; F, female; NA, not available; m, months; AJCC/UICC, The International Union against Cancer/American Joint Committee on Cancer; Fuzhou 1992, the Fuzhou staging system (1992) of nasopharyngeal carcinoma; PF, induction chemotherapy regimen of cisplatin, 5-fluorouracil; TP, induction chemotherapy regimen of docetaxel, cisplatin; TPF, induction chemotherapy regimen of docetaxel, cisplatin, 5-fluorouracil; CCRT, concurrent chemoradiotherapy.