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. 2019 Mar;11(3):972–986. doi: 10.21037/jtd.2019.02.83

Table 2. Characteristics of techniques to identify intersegmental planes in anatomical segmentectomy.

Method Inflation-deflation line Indocyanine green (ICG) Virtual-assisted lung mapping
Target segment deflated Target segment inflated ICG intravenous ICG intrabronchial
Principles Ventilate the lug after clamping or cutting the target bronchus Inflate the segment through the target bronchus by bronchoscopic jet ventilation or direct intubation Intravenously inject ICG after clamping or cutting the target pulmonary artery (target segment does not fluoresce) Stain the segment through the target bronchus by dye injection through a bronchoscope or directly through the endotracheal tube Multiple dye marks made at the corner of the target segment or adjacent segment, or beyond the segment, to obtain resection margins
Timing Intraoperative Intraoperative Intraoperative Preoperative/intraoperative Preoperative
Advantages Very easy and quick Relatively easy Easy and quick Dye remains longer than with intravenous injection (lasts the duration of the operation) Preoperative confirmation made regarding the relationship between the dye marks and the tumor, to secure margins (reproducibility)
No preparation is needed Less interference with thoracoscopic view Repeatable (fluorescence remains for a few minutes) May not need infrared thoracoscopy (fluorescence)
May help to obtain better resection margins Demark the lung parenchyma around the hilum
Disadvantages Interferes with thoracoscopic view Some preparation needed Collateral circulation and emphysematous lung may be misleading Airway secretions and collateral ventilation may obscure intersegmental lines Requires preoperative preparation
Needle-mediated injection is prohibited Correct identification of pulmonary artery is mandatory Requires basic instruments and an available facility (e.g., with fluoroscopy)
Does not demark true intersegmental planes
Intersegmental lines could be obscured because of collateral ventilation or airway secretions Infrared thoracoscopy is required
Once electrocautery is used to develop the intersegmental planes, the inflated lung deflates and demarcation is obscured