Table 1. Univariate analysis of preoperative data.
| Variable | Pregabalin (n=46) | Control (n=46) | P value |
|---|---|---|---|
| Age (years) | |||
| Median | 67 | 70 | 0.17 |
| 20–39, n (%) | 1 (2.2) | 0 (0) | 1.00 |
| 40–64, n (%) | 18 (39.1) | 13 (28.3) | 0.38 |
| 65–89, n (%) | 28 (60.9) | 32 (69.6) | 0.51 |
| Males, n (%) | 33 (71.7) | 28 (60.9) | 0.37 |
| Smoking history, n (%) | 31 (67.4) | 25 (54.3) | 0.28 |
| BMI (kg/m2) | 22.7 | 22.4 | 0.57 |
| AIS score, median | 3 | 3 | 0.72 |
| Preoperative use of hypnotic medication, n (%) | 18 (39.1) | 21 (45.7) | 0.67 |
| eGFR <50 (mL/min), n (%) | 2 (4.3) | 4 (8.7) | 0.67 |
| FVC (L), median | 3.48 | 3.00 | 0.053 |
| FEV1 (L), median | 2.44 | 2.10 | 0.058 |
| Diagnosis, n (%) | |||
| Primary lung cancer | 30 (65.2) | 37 (80.4) | 0.15 |
| Metastatic lung tumor | 9 (19.6) | 3 (6.5) | 0.11 |
| Pneumothorax | 3 (6.5) | 2 (4.3) | 0.82 |
| Other lung diseases | 4 (8.7) | 4 (8.7) | 0.64 |
| Malignant disease, n (%) | 39 (84.8) | 40 (87.0) | 0.72 |
| Right-sided disease, n (%) | 23 (50.0) | 27 (58.7) | 0.53 |
| Procedure type, n (%) | |||
| Partial resection | 11 (23.9) | 5 (10.9) | 0.17 |
| Segmentectomy | 13 (28.3) | 13 (28.3) | 0.59 |
| Lobectomy | 22 (47.8) | 28 (60.9) | 0.29 |
| Complete VATS, n (%) | 32 (69.6) | 34 (73.9) | 0.82 |
| Partial resection | 9 (28.1) | 4 (11.8) | 0.79 |
| Segmentectomy | 6 (18.8) | 7 (20.6) | 0.57 |
| Lobectomy | 17 (53.1) | 23 (67.6) | 0.71 |
| Epidural analgesia, n (%) | 45 (97.8) | 44 (95.7) | 0.88 |
| Intraoperative blood loss (mL), median | 65 | 128 | 0.19 |
| Duration of surgery (min), median | 174 | 187 | 0.39 |
| Chest tube duration (days), median | 2 | 2 | 0.48 |
| Postoperative acute pain requiring additional analgesics, n (%) | |||
| Total | 21 (45.7) | 23 (50.0) | 0.83 |
| After POD 2 | 5 (10.9) | 9 (19.6) | 0.38 |
| Number of analgesic uses, median | |||
| Total | 2 | 2 | 0.95 |
| After POD 2 | 2 | 2 | 0.78 |
| Postoperative hospitalization (days), median | 8 | 9 | 0.14 |
| Complications, n (%) | |||
| Total | 8 (17.4) | 13 (28.3) | 0.32 |
| Prolonged air leak | 4 (8.7) | 6 (13.0) | 0.74 |
| Pneumonia | 0 (0) | 2 (4.3) | 0.49 |
| Arrhythmia | 2 (4.3) | 4 (8.7) | 0.68 |
| Atelectasis | 0 (0) | 1 (2.2) | 1.00 |
| Recurrent laryngeal nerve palsy | 1 (2.2) | 3 (6.5) | 0.62 |
| Delirium | 1 (2.2) | 5 (10.9) | 0.20 |
| Chylothorax | 2 (4.3) | 1 (2.2) | 0.88 |
| Postoperative neuropathic pain, n (%) | 9 (19.6) | 19 (41.3) | 0.0404 |
| Postoperative neuropathic pain onset (day), median | 6 | 6 | 0.55 |
| Duration of postoperative neuropathic pain (days), median | 30 | 90 | 0.024 |
IQR, interquartile range; BMI, body mass index; AIS, Athens Insomnia Scale; eGFR, estimated glomerular filtration rate; FVC, forced vital capacity; FEV1, forced expiratory volume in 1 s; VATS, video-assisted thoracoscopic surgery; POD, postoperative day.