Table 3.

Risk factors for CVST

Variable	Univariate OR (95% CI)	Multivariable OR (95% CI)
Age dichotomous (≥7 vs <7 y)	3.12 (1.07‐9.10)	2.31
Male versus female	1.06 (0.41‐2.71)
T‐ALL versus B‐ALL	1.80 (0.43‐7.46)	1.60 (0.44‐7.30)
MR group versus SR, HR, or unknown	4.14 (1.10‐15.61)	2.64 (0.66‐10.55)
High baseline absolute number of blasts in PB (≥42.5 vs <42.5)	1.05 (0.04‐3.04)

ALL, acute lymphoblastic leukemia; BM, bone marrow; CI, confidence interval; CVST, cerebral venous sinus thrombosis; HR, high risk; MR, medium risk; PB, peripheral blood; SR, standard risk; OR, odds ratio.

Extramedullary disease was defined as presence of a mediastinal mass, testicular involvement, or CNS involvement.