Figure 2.

Mean FIX activity profiles following single 50‐IU/kg doses of N9‐GP and rFIXFc, measured using one‐stage clotting and chromogenic assays. Mean (±SD) FIX activity profiles following single 50‐IU/kg doses of N9‐GP and rFIXFc are shown, measured using one‐stage clotting assays (A) and the chromogenic assay (B). Panel (C) collates the mean plots with an insert magnifying FIX activity over the first 24 h. The aPTT reagents used for the one‐stage clotting assay were SynthAFax and Actin FSL for N9‐GP and rFIXFc, respectively. The ROX factor IX kit was used for the chromogenic assay with both treatments. All assays were calibrated using NHP. aPTT, activated partial thromboplastin time; FIX, factor IX; NHP, normal human plasma; PK, pharmacokinetic, rFIXFc, recombinant factor IX‐Fc fusion protein; SD, standard deviation