. 2019 Apr 12;5:129–138. doi: 10.1016/j.trci.2019.02.004

Table 3.

Statistical summary of the preclinical Alzheimer's cognitive composite (PACC), memory composite, and learning composite models, including beta coefficients and standard errors

Predictor variable	Linear mixed effects models
	PACC			Memory composite			Learning composite
	T-tau	NG	NFL	T-tau	NG	NFL	T-tau	NG	NFL
Age (centered)	−0.031^∗	−0.031^∗	−0.032^∗	−0.030^†	−0.029^†	−0.032^∗	−0.025^∗	−0.024^∗	−0.027^∗
	(0.006)	(0.007)	(0.006)	(0.009)	(0.009)	(0.009)	(0.007)	(0.007)	(0.007)
Sex	0.158^‡	0.153^‡	0.143^‡	0.356^∗	0.344^∗	0.344^∗	0.188^‡	0.179^‡	0.186^‡
	(0.070)	(0.070)	(0.068)	(0.103)	(0.103)	(0.102)	(0.077)	(0.076)	(0.077)
APOE ε4	−0.030	−0.032	−0.031	−0.151	−0.146	−0.142	−0.114	−0.104	−0.104
	(0.070)	(0.071)	(0.069)	(0.103)	(0.104)	(0.102)	(0.078)	(0.078)	(0.077)
WRAT Score	0.040^∗	0.039^∗	0.030^∗	0.056^∗	0.054^∗	0.049^∗	0.039^∗	0.037^∗	0.035^∗
	(0.008)	(0.008)	(0.008)	(0.012)	(0.012)	(0.012)	(0.009)	(0.009)	(0.009)
Age difference	0.008	0.007	0.003	0.041^∗	0.041^∗	0.038^∗	0.040^∗	0.040^∗	0.038^∗
	(0.007)	(0.007)	(0.007)	(0.009)	(0.009)	(0.009)	(0.007)	(0.007)	(0.007)
Amyloid positivity	−0.101	−0.075	−0.038	−0.169	−0.101	−0.108	−0.139	−0.079	−0.120
	(0.082)	(0.081)	(0.077)	(0.120)	(0.117)	(0.111)	(0.093)	(0.090)	(0.086)
P-tau positivity	−0.049	0.0001	0.065	0.041	0.189	0.157	0.078	0.216	0.121
	(0.110)	(0.110)	(0.096)	(0.162)	(0.161)	(0.139)	(0.125)	(0.123)	(0.107)
T-tau	0.044			0.068			0.028
	(0.041)			(0.060)			(0.046)
NG		0.009			−0.034			−0.068
		(0.040)			(0.058)			(0.044)
NFL			−0.012			0.017			0.040
			(0.041)			(0.059)			(0.046)
Age × amyloid positivity	−0.008	−0.008	0.001	−0.012	−0.012	−0.002	−0.006	−0.006	0.001
	(0.009)	(0.009)	(0.008)	(0.013)	(0.013)	(0.012)	(0.010)	(0.010)	(0.009)
Age × P-tau positivity	−0.018	−0.018	−0.001	−0.052^†	−0.052^†	−0.032	−0.029	−0.031	−0.015
	(0.014)	(0.014)	(0.012)	(0.020)	(0.020)	(0.017)	(0.016)	(0.016)	(0.014)
Age × T-tau	0.0001			0.006			0.004
	(0.005)			(0.007)			(0.005)
Age × NG		0.0002			0.006			0.004
		(0.005)			(0.007)			(0.005)
Age × NFL			−0.021^∗			−0.016^†			−0.011^‡
			(0.004)			(0.006)			(0.005)
Constant	−2.080^∗	−2.029^∗	−1.557^∗	−2.944^∗	−2.845^∗	−2.605^∗	−1.989^∗	−1.935^∗	−1.806^∗
	(0.403)	(0.403)	(0.398)	(0.591)	(0.591)	(0.596)	(0.443)	(0.439)	(0.449)
Observations	559	559	559	559	559	559	559	559	559
AIC	548.5	549.6	511.2	866.8	868.1	860.1	661.8	660.4	656.7

Abbreviations: APOE ε4, apolipoprotein E gene ε4; WRAT, Wide Range Achievement Test; age difference, years between lumbar puncture and cognitive examinations; p-tau, tau phosphorylated at threonine 181; t-tau, total tau; NG, neurogranin; NFL, neurofilament light protein; AIC, Akaike information criterion.

^∗

P < .001.

^†

P < .01.

^‡

P < .05.