Figure 1.
Schematic Diagram of the Ex Vivo Bioreactor System
Aptamer and controls were delivered to the explanted pig artery via the perfusion catheter. The specific treatment zone within the explanted pig arteries were between the proximal and distal occlusion balloons of the perfusion catheter. Following aptamer delivery, a computer-controlled gear pump generated and circulated culture medium at physiological flow rates. The treated artery and flow reservoir were housed within a CO2 incubator.