Figure 4.

Schematic Illustration of the Perfusion Catheter

Two occluding balloons are deployed to momentarily stop circulating flow to a portion of a vessel. Trapped blood within the perfusion chamber is then flushed with saline. Drug can be delivered through the inflow port. The outflow port can be closed and drug delivered to the lesion with external pressure. The delivery pressure is measured by a fiberoptic pressure sensor located at the inlet port. Following the delivery of the drug, the remaining drug in the chamber is cleared through the outflow port to ensure no additional drug is introduced into the circulatory system.