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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Sci Immunol. 2018 Aug 24;3(26):eaat2738. doi: 10.1126/sciimmunol.aat2738

Fig. 7. NSA treatment extends survival in the LPS model of sepsis.

Fig. 7.

(A to C) C57BL/6J mice (9 or 10 per group) were injected with LPS (25 mg/kg) and with NSA or DMSO (20 mg/kg) 30 min before and 10 hours after LPS administration. Volume per injection of NSA or DMSO was about 25 μl per mouse. Serum levels of IL-6 and IL-1β, measured by sandwich ELISA, were taken 6 hours after the administration of LPS. Cytokine data are means ± SE. Survival curves were analyzed by log-rank (Mantel-Cox) test demonstrating an increase in median survival of 9 hours in the NSA treatment group (P <0.0001). *P < 0.05, **P < 0.01.