Fig. 5.

MFSD12 regulates melanoma cell proliferation via the PI3K–AKT signaling pathway. a Several signal molecules are presented in A2058-shRNA cells, M14-shRNA cells, and their control cells. b A2058-Vector cells treated with LY294002 compared with A2058-Vector cells not treated with LY294002; A2058-shRNAs applied to colony formation and CCK-8 assays. c M14-Vector cells treated with LY294002 compared with M14-Vector cells not treated with LY294002; M14-shRNAs applied to colony formation and CCK-8 assays. d Western blot bands for MFSD12, CDK2, cyclin D1, and cyclin E1; AKT signal molecules are shown in the indicated cells. GAPDH was used as the internal control. *p < 0.05; **p < 0.01