Table 2. . Quantities of cortisol metabolites in the urine of 14 nonsmokers and 21 smokers.

Metabolites	Smokers		Nonsmokers
	Level (pmol/mg creatinine)	Relative abundance	Level (pmol/mg creatinine)	Relative abundance
Cortisol	3–58	<0.07%	0.4–61†	<0.04%
Cortisol gluc	8–565	<0.02%	1–17	<0.03%
THF/A-THF	1–71	<0.03%	30–1635	<0.94%
THF/A-THF gluc	612–9139	0.14–9.50%	352–11,584	0.29–5.38%
Dihydrocortisol	4–3628	<0.01–2.52%	0.4–56†	<0.18%
Dihydrocortisol gluc	14,542–280,266	2.88–83.40%	14,064–408,434	13.72–92.34%
Cortisol sulfate	28–179	<0.11%	4–148	<0.03%
6-hydroxycortisol	5–616	<0.33%	1–1871†	<0.01–6.08%
Cortisone	18–184	<0.17%	11–231	<0.18%
Cortisone gluc	18–2132	<0.01–2.34%	12–562	<0.31%
THE	1–243†	<0.17%	0.5–217†	<0.08%
THE gluc	2559–34,770	0.57–9.55%	988–41,734	2.35–14.85%
Dihydrocortisone	14–5213	<0.01–5.15%	2–2405†	<0.01–1.38%
Dihydrocortisone gluc	19,447–1,868,017	9.39–95.39%	4460–196,412	1.41–69.85%
Cortisone sulfate	1–380†	<0.14%	1–217†	<0.08%
Total dihydrocortisol + dihydrocortisone + THF/A-THF + THE		97.04–99.96%		92.91–99.82%

^†When the measured levels were below the LOD, half of the LOD values of the metabolites were reported herein.

A-THF: Allo-3α-tetrahydrocortisol; THE: 5β-tetrahydrocortisone; THF: 5β-tetrahydrocortisol.