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. 2018 Sep 12;33(3):612–624. doi: 10.1038/s41375-018-0253-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Impact of decreased GNB2 expression or depleted Gnb2 genome in MLL-AML. a, b, c Growth curves (cell numbers) and GNB2 expression values of 3 human MLL-AML cell lines (a NOMO1, b MOLM13, and c THP1) treated with GNB2 shRNA and control scramble shRNA. Each experiment was performed in triplicate. d, e By genome-wide CRISPR-Cas9 screens, read counts of six sgRNAs targeting per exon (exon 1 (d) and 2 (e)) in Gnb2 were measured after a 16-day incubation period to confirm potential oncogenic function of Gnb2 in MLL/AF9-AML