Table 1.
The parameters underlying data generation for an N-of-1 study. The parameters are divided into study design parameters (D), treatment-related parameters (T), measurement parameters (M), and outcome-related parameters (O).
| Parameter | Type | Description |
| {t1,…,tn} | D | Sampling times |
| N | D | Number of blocks (each with J periods in random order) |
| J | D | Number of treatment periods per block |
| P | D | Treatment period length |
| E1,…,EJ | T | Effect sizes for treatments 1 through J |
| τ1,…, τJ | T | Run-in time constants for treatments 1 through J |
| γ1,…, γJ | T | Wash-out time constants for treatments 1 through J |
| ∝ | O | Sensitivity to treatment effect |
| σb2 | O | Variance of baseline drift process |
| σp2 | O | Variance of process noise |
| σo2 | M | Variance of observation noise |