Table 2.
Patient characteristics of included studies.
| Study | No. Patients (n) | Sex (n, %) | Age (Years) | Primary Tumour Location | LM Size in cm (Median, Range) | Non-Functional NETs (n, %) | Resection of Primary Tumour (n, %) | Resectable/Unresectable LM | Uni-/Bilobar Metastases | Extrahepatic Disease (n, %) | WHO 2010 Grade | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Male | Female | Pancreas (n, %) | Small Bowel (n, %) | Other/Unknown (n, %) | ||||||||||
| Watzka et al. [27] | 204 | 111 (54) | 93 (46) | 58 ± 15 (60) * | 58 (28) | 73 (36) | 73 (36) | N/A | 123 (60) | 165 (81) | Mixed | N/A | N/A | All |
| Partelli et al. [26] | 166 | 92 (55) | 74 (45) | N/A ‡ | 166 | 0 | 0 | LM resection 0.8 cm (0.3–1.7 cm); no resection at all 3.4 cm (1–7 cm) † | 152 (92) | 91 (55) | Resectable | Both | N/A | All |
| Citterio et al. [21] | 139 | 67 (48) | 72 (52) | 56 (51–55) † | 36 (26) | 66 (47) | 37 (27) | N/A | 0 | 93 (67) | Mixed | N/A | N/A | 1–2 |
| Du et al. [24] | 130 | 69 (53) | 61 (47) | 49.0 ± 12.1 (N/A) * | 85 (65) | 7 [5] | 38 (30) | Mean 4.1 cm (range 3–15 cm) | 100 (77) | 68 (52) | Mixed | N/A | N/A | All |
| Bertani et al. [17] | 121 | 66 (55) | 58 (45) | 54.6 ± 12.6 (54.5) * | 121 (100) | 0 | 0 | N/A | 29 (24) | 63 (52) | Unresectable | N/A | 28 (23) | All |
| Boyar et al. [18] | 114 | 61 (54) | 83 (46) | 57 (32–83) † | 111 (97) | 0 | 3 [3] | N/A | 89 (78) | 46 (40) | Mixed | N/A | 51 (45) | 1–2 |
| Chamberlain et al. [19] | 85 | 37 (44) | 48 (56) | 52 (20–79) † | 42 (49) | 0 | 43 (51) | N/A | 49 (58) | 36 (42) | Mixed | Both | 45 (53) | 1–2 |
| Musunuru et al. [25] | 48 | 30 (63) | 18 (37) | N/A | 15 (31) | 0 | 33 (69) | Embolization 8.9 ± 6.1 cm; chemotherapy 3.7 ± 2.9 cm; any resection 4.5 ± 2.3 cm * | N/A | 12 (25) | Unclear | Both | 0 | N/A |
| Chen et al. [20] | 38 | 24 (63) | 14 (37) | N/A ‡ | 11 (29) | 9 (24) | 18 (47) | N/A | 9 (24) | 12 (32) | Mixed | Bilobar | 0 | N/A |
| Dousset et al. [23] | 34 | 18 (53) | 17 (47) | 49.5 (29–76) † | 17 (50) | 9 (26) | 8 (24) | N/A | 5 (15) | 21 (62) | Mixed | Bilobar | 0 | N/A |
| Coppa 2001 et al. [22] | 29 | 13 (45) | 16 (55) | N/A ‡ | 0 | 0 | 29§ | N/A | N/A | 11 (38) | Mixed | N/A | 0 | N/A |
* mean ± SD (median); † median (range); ‡ Age was reported for each subgroup separately; § 21 have a pancreatic or ileal origin, whilst 8 originated in the lung or rectum; N/A: not available.