Table 2.
Genotype distributions of HOTAIR gene polymorphisms in 862 controls and 431 patients with urothelial cell carcinoma.
| Variable | Controls (n = 862) n (%) | Patients (n = 431) n (%) | OR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|
| rs920778 | ||||
| TT | 447 (51.9%) | 217 (50.3%) | 1.00 (reference) | 1.00 (reference) |
| TC | 360 (41.8%) | 176 (40.8%) | 1.01 (0.79–1.28) | 0.96 (0.73–1.27) |
| CC | 55 (6.4%) | 38 (8.8%) | 1.42 (0.91–2.22) | 1.60 (0.96–2.68) |
| TC + CC | 415 (48.1%) | 214 (49.7%) | 1.06 (0.84–1.34) | 1.04 (0.80–1.35) |
| rs1899663 | ||||
| GG | 550 (63.8%) | 265 (61.5%) | 1.00 (reference) | 1.00 (reference) |
| GT | 285 (33.1%) | 148 (34.3%) | 1.08 (0.84–1.38) | 0.95 (0.71–1.25) |
| TT | 27 (3.1%) | 18 (4.2%) | 1.38 (0.75–2.56) | 1.85 (0.92–3.73) |
| GT + TT | 312 (36.2%) | 166 (38.5%) | 1.10 (0.87–1.40) | 1.01 (0.77–1.32) |
| rs4759314 | ||||
| AA | 727 (84.3%) | 363 (84.2%) | 1.00 (reference) | 1.00 (reference) |
| AG | 128 (14.8%) | 67 (15.5%) | 1.05 (0.76–1.45) | 1.07 (0.74–1.54) |
| GG | 7 (0.8%) | 1 (0.2%) | 0.29 (0.04–2.33) | 0.59 (0.06–5.58) |
| AG + GG | 135 (15.7%) | 68 (15.8%) | 1.01 (0.73–1.39) | 1.05 (0.73–1.51) |
| rs12427129 | ||||
| CC | 691 (80.2%) | 350 (81.2%) | 1.00 (reference) | 1.00 (reference) |
| CT | 167 (19.4%) | 76 (17.6%) | 0.90 (0.67–1.21) | 1.00 (0.71–1.41) |
| TT | 4 (0.5%) | 5 (1.2%) | 2.47 (0.66–9.25) | 2.23 (0.44–11.23) |
| CT + TT | 171 (19.8%) | 81 (18.8%) | 0.94 (0.70–1.26) | 1.03 (0.74–1.44) |
The odds ratio (OR) and 95% confidence interval (CI) were estimated by logistic regression models. The adjusted OR (AOR) and the 95% CI were estimated by multivariable logistic regression models after controlling for age, gender, and tobacco consumption.