Table 3.
Genotype distributions of HOTAIR gene polymorphisms among 455 female subjects.
| Variable | Controls (n = 296), n (%) | Patients (n = 159), n (%) | OR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|
| rs920778 | ||||
| TT | 155 (52.4%) | 79 (49.7%) | 1.000 (reference) | 1.00 (reference) |
| TC | 120 (40.5%) | 61 (38.4%) | 1.00 (0.66–1.50) | 1.03 (0.62–1.71) |
| CC | 21 (7.1%) | 19 (11.9%) | 1.78 (0.90–3.49) | 1.96 (0.84–4.61) |
| TC + CC | 141 (47.6%) | 80 (50.3%) | 1.11 (0.76–1.64) | 1.16 (0.72–1.88) |
| rs1899663 | ||||
| GG | 191 (64.5%) | 95 (59.7%) | 1.00 (reference) | 1.00 (reference) |
| GT | 94 (31.8%) | 57 (35.8%) | 1.22 (0.81–1.84) | 0.92 (0.55–1.54) |
| TT | 11 (3.7%) | 7 (4.4%) | 1.28 (0.48–3.41) | 1.79 (0.58–5.51) |
| GT + TT | 105 (35.5%) | 64 (40.3%) | 1.23 (0.82–1.82) | 1.00 (0.61–1.63) |
| rs4759314 | ||||
| AA | 256 (86.5%) | 126 (79.2%) | 1.00 (reference) | 1.00 (reference) |
| AG | 35 (11.8%) | 32 (20.1%) |
1.86 (1.10–3.14)
p = 0.021 |
1.98 (1.03–3.82)
p = 0.042 |
| GG | 5 (1.7%) | 1 (0.6%) | 0.41 (0.05–3.52) | 1.12 (0.09–13.66) |
| AG + GG | 40 (13.5%) | 33 (20.8%) |
1.68 (1.01–2.79)
p = 0.046 |
1.92 (1.01–3.64)
p = 0.047 |
| rs12427129 | ||||
| CC | 240 (81.1%) | 128 (80.5%) | 1.00 (reference) | 1.00 (reference) |
| CT | 53 (17.9%) | 28 (17.6%) | 0.99 (0.60–1.64) | 1.50 (0.80–2.80) |
| TT | 3 (1%) | 3 (1.9%) | 1.88 (0.37–9.42) | 1.40 (0.19–10.56) |
| CT+TT | 56 (18.9%) | 31 (19.5%) | 1.04 (0.64–1.69) | 1.49 (0.81–2.73) |
Bold font indicates statistical significance (p < 0.05). The odds ratio (OR) and 95% confidence interval (CI) were estimated by logistic regression models. The adjusted OR (AOR) and 95% confidence interval were estimated by multivariable logistic regression models after controlling for age, gender, and tobacco consumption.