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. 2019 Mar 5;5(1):22. doi: 10.3390/jof5010022

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Candidalysin regulates the host endothelial FGF-2 response. (a) HUVECs were challenged with BWP17 + CIp30 (WT), ece1△/△, ece1△/△ + ECE1, or ece1△/△ + ECE1_△184-279 for 24 h. FGF-2 levels were measured using ELISA. One-way ANOVA was significant (p = 0.001). Dunnett’s multiple comparison demonstrated that compared to the uninfected group (Mock), only HUVECs challenged with BWP17 + CIp30 or ece1△/△ + ECE1 showed a statistically significant increase in the FGF-2 response (p < 0.05), as indicated by (*). (b) HUVECs were treated with vehicle control (water) or Candidalysin peptide for 24 h. A two-tailed t-test showed a statistically significant difference between the two groups (p = 0.049), indicated as (*).