Table 2.
Meta-analysis results of associations between juvenile idiopathic arthritis (JIA) and the PTPN22 1858 C/T polymorphism from observational studies.
| Author, Year | No. of Studies | Comparison | OR (95% CI) | p-Value | Model | Disease | Ethnicity | I2 (%) | Egger’s p-Value | Power OR 1.2 | Power OR 1.5 | FPRP Values at Prior Probability | BFDP 0.001 | BFDP 0.000001 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR 1.2 | OR 1.5 | ||||||||||||||||
| 0.001 | 0.000001 | 0.001 | 0.000001 | ||||||||||||||
| DI Y, 2015 [14S] | 7 | T vs. C | 1.38 (1.04–1.83) | 0.025 | R | JIA (cases n < 500) | Overall mixed | 72.4 | 0.619 | 0.166 | 0.719 | 0.993 | 1.000 | 0.972 | 1.000 | 0.997 | 1.000 |
| DI Y, 2015 [14S] | 4 | T vs. C | 1.55 (1.39–1.72) | <0.001 | R | JIA (cases n ≥ 500) | Overall mixed | 8.00 | 0.309 | 0.000 | 0.300 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| DI Y, 2015 [14S] | 8 | T vs. C | 1.52 (1.32–1.76) | <0.001 | R | JIA (population-based) | Overall mixed | 55.5 | 0.979 | 0.001 | 0.430 | 0.027 | 0.965 | 0.000 | 0.048 | 0.003 | 0.738 |
| DI Y, 2015 [14S] | 3 | T vs. C | 1.36 (1.15–1.60) | <0.001 | R | JIA (hospital-based) | Overall mixed | 8.80 | 0.882 | 0.066 | 0.881 | 0.761 | 1.000 | 0.191 | 0.996 | 0.878 | 1.000 |
| DI Y, 2015 [14S] | 4 | T vs. C | 1.52 (1.32–1.78) | <0.001 | F | JIA | American | 45.7 | 0.585 | 0.002 | 0.435 | 0.108 | 0.992 | 0.000 | 0.317 | 0.022 | 0.957 |
| DI Y, 2015 [14S] | 6 | T vs. C | 1.36 (1.01–1.83) | 0.041 | R | JIA | Augean | 74.4 | 0.555 | 0.204 | 0.741 | 0.995 | 1.000 | 0.983 | 1.000 | 0.998 | 1.000 |
| DI Y, 2015 [14S] | 11 | T vs. C | 1.42 (1.20–1.68) | <0.001 | R | JIA | Overall mixed | 61.6 | 0.303 | 0.025 | 0.739 | 0.636 | 0.999 | 0.056 | 0.983 | 0.676 | 1.000 |
| DI Y, 2015 [14S] | 9 | T vs. C | 1.48 (1.36–1.62) | <0.001 | F | JIA (Adjusted) | Overall mixed | 8.8 | 0.268 | NA | NA | NA | NA | NA | NA | 0.000 | 0.000 |
| Kaalla M, 2013 [15S] | 8 | T vs. C | 1.44 (1.31, 1.60) | <0.0001 | F | RA | Overall mixed | - | - | 0.000 | 0.776 | 0.000 | 0.033 | 0.000 | 0.000 | 0.000 | 0.002 |
| Kaalla M, 2013 [15S] | T vs. C | 2.05 (1.37, 3.77) | <0.0005 | - | RF+ | Overall mixed | - | - | 0.042 | 0.157 | 0.998 | 1.000 | 0.993 | 1.000 | 0.998 | 1.000 | |
| Kaalla M, 2013 [15S] | T vs. C | 1.56 (1.21, 2.02) | 0.0007 | - | RF− | Overall mixed | - | - | 0.023 | 0.383 | 0.970 | 1.000 | 0.660 | 0.999 | 0.970 | 1.000 | |
| Kaalla M, 2013 [15S] | T vs. C | 1.45 (1.18, 1.79) | <0.0005 | - | RA (Oligoarticular) | Overall mixed | - | - | 0.039 | 0.624 | 0.933 | 1.000 | 0.466 | 0.999 | 0.951 | 1.000 | |
| Zheng J, 2012 [5S] | 7 | T vs. C | 1.54 (1.40–1.70) | 1.0 × 10−16 | - | JIA | Overall mixed | - | - | NA | NA | NA | NA | NA | NA | 0.000 | 0.000 |
| Lee YH, 2012[16S] | 7 | T vs. C | 1.311 (1.205–1.427) | <1.8 × 10−8 | - | JIA | European | 32.2 | 0.353 | 0.020 | 0.999 | 0.000 | 0.019 | 0.000 | 0.000 | 0.000 | 0.033 |
| Lee YH, 2007 [13S] | 2 | TT vs. CC | 1.89 (1.09–3.29) | 0.02 | - | JIA | Overall mixed | 0.00 | - | 0.054 | 0.207 | 0.998 | 1.000 | 0.992 | 1.000 | 0.998 | 1.000 |
JIA, juvenile idiopathic arthritis; OR, odds ratio; R, random; F, fixed; S, supplementary; FPRP, false-positive report probability; BFDP, Bayesian false discovery probability. Each comparison of genetic associations was regarded as noteworthy when FPRP of <0.2 or BFDP of <0.8 or both are fulfilled and the values were bolded when the results are significant by FPRP or BFDP. NAs are expressed when information is not available by FPRP calculations.