Table 3.
Meta-analysis results of associations between systemic lupus erythematosus (SLE) and the PTPN22 1858 C/T polymorphism from observational studies.
| Author, Year | No. of Studies | Comparison | OR (95% CI) | p-Value | Model | Disease | Ethnicity | I2 (%) | Egger’s p-Value | Power OR 1.2 | Power OR 1.5 | FPRP Values at Prior Probability | BFDP 0.001 | BFDP 0.000001 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR 1.2 | OR 1.5 | ||||||||||||||||
| 0.001 | 0.000001 | 0.001 | 0.000001 | ||||||||||||||
| Hu LY, 2017 [17S] | 17 | TT+CT vs. CC | 1.53 (1.346–1.742) | 9.17 × 10−11 | R | SLE | Overall mixed | 44.2 | 0.05 | 0.000 | 0.378 | 0.001 | 0.481 | 0.000 | 0.000 | 0.000 | 0.019 |
| Hu LY, 2017 [17S] | 4 | T vs. C | 2.56 (1.796–3.665) | 2.219 × 10−7 | F | SLE | American | 0.00 | >0.05 | 0.000 | 0.002 | 0.938 | 1.000 | 0.122 | 0.993 | 0.438 | 0.999 |
| Hu LY, 2017 [17S] | 11 | T vs. C | 1.39 (1.261–1.552) | 2.153 × 10−10 | F | SLE | European | 32.8 | 0.938 | 0.002 | 0.906 | 0.000 | 0.108 | 0.000 | 0.000 | 0.000 | 0.025 |
| Hu LY, 2017 [17S] | 2 | TT+CT vs. CC | 5.08 (2.053–12.569) | 4.315 × 10−4 | F | SLE | African | 0.00 | >0.05 | 0.001 | 0.004 | 0.998 | 1.000 | 0.991 | 1.000 | 0.997 | 1.000 |
| de Lima SC, 2017 [18S] | 19 | T vs. C | 1.54 (1.38–1.72) | 0.000 | F | SLE | Overall mixed | - | - | 0.000 | 0.320 | 0.000 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
| de Lima SC, 2017 [18S] | NA | T vs. C | 1.47 (1.29–1.66) | 0.0000 | F | SLE | Caucasian | 13.96 | - | 0.001 | 0.628 | 0.001 | 0.495 | 0.000 | 0.001 | 0.000 | 0.067 |
| de Lima SC, 2017 [18S] | NA | T vs. C | 2.41 (1.68–3.44) | 0.0000 | F | SLE | Latin | 0.000 | - | 0.000 | 0.005 | 0.954 | 1.000 | 0.219 | 0.996 | 0.667 | 1.000 |
| Shi L, 2013 [19S] | 4 | T vs. C | 2.33 (1.78–3.04) | <0.00001 | F | SLE | Overall mixed | 0.00 | <0.05 | 0.000 | 0.001 | 0.475 | 0.999 | 0.001 | 0.438 | 0.002 | 0.698 |
| Shi L, 2013[19S] | 4 | TC vs. CC+TT | 2.33 (1.78–3.04) | < 0.00001 | F | SLE | Overall mixed | 0.00 | - | 0.000 | 0.001 | 0.475 | 0.999 | 0.001 | 0.438 | 0.002 | 0.698 |
| Lea WW, 2011 [20S] | 11 | T vs. C | 1.56 (1.34–1.822) | 2.0× 10−8 | R | SLE | Overall mixed | 49.3 | 0.405 | 0.000 | 0.310 | 0.041 | 0.977 | 0.000 | 0.060 | 0.003 | 0.750 |
| Zheng J, 2012 [5S] | 14 | T vs. C | 1.46 (1.31–1.62 | 7.33 × 10−13 | - | SLE | Overall mixed | - | - | 0.000 | 0.695 | 0.000 | 0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
| Ramirez M, 2012 [8S] | 2 | T vs. C | 2.65 (0.74–4.05) | 1.0 × 10−5 | F | SLE | Overall mixed | NA | - | 0.000 | 0.004 | 0.982 | 1.000 | 0.610 | 0.999 | 0.916 | 1.000 |
| Lea WW, 2011 [20S] | 7 | T vs. C | 1.49 (1.28–1.735) | 2.8 × 10−8 | R | SLE | European | 46.5 | 0.908 | 0.003 | 0.534 | 0.096 | 0.991 | 0.001 | 0.346 | 0.027 | 0.965 |
| Lea WW, 2011 [20S] | 3 | T vs. C | 2.35 (1.644–3.373) | 2.9 × 10−6 | F | SLE | Hispanic | 0.00 | 0.639 | 0.000 | 0.007 | 0.962 | 1.000 | 0.300 | 0.998 | 0.769 | 1.000 |
| Lee YH, 2007 [13S] | 5 | CT vs. CC | 1.41 (1.22–1.63) | <0.00001 | - | SLE | Overall mixed | 0.00 | - | 0.015 | 0.799 | 0.189 | 0.996 | 0.004 | 0.810 | 0.172 | 0.995 |
SLE, systemic lupus erythematosus; OR, odds ratio; R, random; F, fixed; S, supplementary; FPRP, false-positive report probability; BFDP, Bayesian false discovery probability. Each comparison of genetic associations was regarded as noteworthy when FPRP of <0.2 or BFDP of <0.8 or both are fulfilled and the values were bolded when the results are significant by FPRP or BFDP.