Table 4.
Meta-analysis results of associations between vasculitides and the PTPN22 1858 C/T polymorphism from observational studies.
| Author, Year | No. of Studies | Comparison | OR (95% CI) | p-Value | Model | Disease | Ethnicity | I2 (%) | Egger’s p-Value | Power OR 1.2 | Power OR 1.5 | FPRP Values at Prior Probability | BFDP 0.001 | BFDP 0.000001 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR 1.2 | OR 1.5 | ||||||||||||||||
| 0.001 | 0.000001 | 0.001 | 0.000001 | ||||||||||||||
| ANCA-associated vasculitis | |||||||||||||||||
| Rahmattulla, 2015 [21S] | 4 | CT +TT vs. CC | 1.39 (1.24–1.56) | <0.001 | R | ANCA-associated vasculitis | Overall mixed | 0.00 | - | 0.006 | 0.902 | 0.004 | 0.780 | 0.000 | 0.024 | 0.002 | 0.654 |
| Cao Y, 2015 [22S] | 4 | A vs. G | 1.44 (1.26–1.64) | 2.27 × 10−5 | F | ANCA | White population | 0.00 | >0.05 | 0.003 | 0.731 | 0.013 | 0.929 | 0.000 | 0.051 | 0.004 | 0.788 |
| Cao Y, 2015 [22S] | 3 | A vs. G | 1.72 (1.35–2.20) | 1.25 × 10−7 | F | GPA | White population | 0.00 | >0.05 | 0.002 | 0.138 | 0.883 | 1.000 | 0.102 | 0.991 | 0.679 | 1.000 |
| Cao Y, 2015 [22S] | 2 | A vs. G | 1.53 (1.08–2.15) | 0.02 | F | MPA | White population | 0.00 | >0.05 | 0.081 | 0.455 | 0.994 | 1.000 | 0.969 | 1.000 | 0.996 | 1.000 |
| Cao Y, 2015 [22S] | 2 | A vs. G | 1.74 (1.25–2.43) | 0.001 | F | ANCA(miao)(with proteinase 3) | White population | 0.00 | >0.05 | 0.015 | 0.192 | 0.987 | 1.000 | 0.857 | 1.000 | 0.985 | 1.000 |
| Cao Y, 2015 [22S] | 2 | A vs. G | 1.94 (0.64–5.85) | 0.24 | R | ANCA(miao)(myeloperoxidase) | White population | 77 | >0.05 | 0.197 | 0.324 | 0.999 | 1.000 | 0.999 | 1.000 | 0.999 | 1.000 |
| Lee YH, 2012 [23S] | 2 | T vs. C | 2.04 (1.53–2.719) | 1.02 × 10−6 | F | ANCA+WG | Caucasian | 0 | NA | 0.000 | 0.017 | 0.882 | 1.000 | 0.056 | 0.983 | 0.375 | 0.998 |
| Lee YH, 2012 [23S] | 2 | T vs. C | 3.43 (1.18–10.36) | 0.029 | F | ANCA+ vs. ANCA | Overall mixed | 0 | NA | 0.031 | 0.071 | 0.999 | 1.000 | 0.998 | 1.000 | 0.999 | 1.000 |
| Lee YH, 2012 [23S] | 3 | T vs. C | 1.41 (1.23–1.63 | 1.59 × 10−6 | F | AAV | Caucasian | 0.00 | 0.481 | 0.011 | 0.791 | 0.119 | 0.993 | 0.002 | 0.656 | 0.091 | 0.990 |
| Lee YH, 2012 [23S] | 2 | T vs. C | 1.83 (1.37–2.43) | 3.09 × 10−5 | F | WG | Caucasian | 0 | NA | 0.002 | 0.086 | 0.945 | 1.000 | 0.271 | 0.997 | 0.841 | 1.000 |
| Zheng J, 2012 [5S] | 2 | T vs. C | 1.45 (1.24–1.69) | 3.07 × 10−6 | - | ANCA-associated(miao)vasculitis | Overall mixed | - | - | 0.008 | 0.668 | 0.204 | 0.996 | 0.003 | 0.748 | 0.125 | 0.993 |
| Giant cell arteritis | |||||||||||||||||
| Lester S, 2016 [24S] | 7 | T vs. C | 1.33 (1.16–1.52) | 3.0 × 10−5 | R | GCA | Overall mixed | 4.72 | - | 0.066 | 0.961 | 0.302 | 0.998 | 0.029 | 0.967 | 0.541 | 0.999 |
| Lester S, 2016 [24S] | 5 | T vs. C | 1.21 (1.03–1.43) | <0.05 | R | GCA | Northern European | - | - | 0.461 | 0.994 | 0.982 | 1.000 | 0.962 | 1.000 | 0.997 | 1.000 |
| Lester S, 2016 [24S] | 2 | T vs. C | 1.56 (1.28–1.91) | <0.05 | R | GCA | Southern European | - | - | 0.006 | 0.352 | 0.750 | 1.000 | 0.045 | 0.979 | 0.572 | 0.999 |
ANCA, anti-neutrophil cytoplasmic antibody; AAV, ANCA-associated vasculitis; WG, Wegener’s granulomatosis; GCA, giant cell arteritis; GPA, granulomatosis with polyangiitis; MPA, microscopic polyangiitis; OR, odds ratio; R, random; F, fixed; S, supplementary; FPRP, false-positive report probability; BFDP, Bayesian false discovery probability. Each comparison of genetic associations was regarded as noteworthy when FPRP of <0.2 or BFDP of <0.8 or both are fulfilled and the values were bolded when the results are significant by FPRP or BFDP.