Table 8.
Meta-analysis results of gene variants from genome-wide association studies showing significant p-value (<5 × 10−8).
| Author, Year | No. of Studies | Comparison | OR (95% CI) | p-Value | Model | Disease | Ethnicity | I2 (%) | Power OR 1.2 | Power OR 1.5 | FPRP Values at Prior Probability | BFDP 0.001 | BFDP 0.000001 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR 1.2 | OR 1.5 | |||||||||||||||
| 0.001 | 0.000001 | 0.001 | 0.000001 | |||||||||||||
| Bowes J, 2014 [47S] | 4 | T vs. C | 1.32 (1.21–1.45) | 1.49 × 10−9 | - | PsA | Caucasian | 0.023 | 0.996 | 0.000 | 0.228 | 0.000 | 0.007 | 0.023 | 0.001 | 0.349 |
| Gregersen PK, 2012 [48S] | 3 | T vs. C | 1.71 (1.44–2.02) | 3.72 × 10−10 | - | MG | North European | 0.000 | 0.062 | 0.018 | 0.947 | 0.000 | 0.004 | 0.000 | 0.000 | 0.095 |
| Thompson SD, 2010 [49S] | 2 | additive | 1.64 (1.44–1.87) | 1.90 × 10−13 | - | JIA | Initial + Replication | 0.000 | 0.091 | 0.000 | 0.088 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| Coenen MJ, 2009 [50S] | 2 | T vs. C | 1.67 (1.52–1.84) | 2.0 × 10−27 | R | RA | Caucasian European(miao)(Dutch+ UK) | NA | NA | NA | NA | NA | NA | NA | 0.000 | 0.000 |
RA, rheumatoid arthritis; PsA, psoriatic arthritis; MG, myasthenia gravis; JIA, juvenile idiopathic arthritis; OR, odds ratio; R, random; S, supplementary; FPRP, false-positive report probability; BFDP, Bayesian false discovery probability. Each comparison of genetic associations was regarded as noteworthy when FPRP of <0.2 or BFDP of <0.8 or both are fulfilled and the values were bolded when the results are significant by FPRP or BFDP. NAs are expressed when information is not available by FPRP calculations.