Table 9.
Meta-analysis results of the PTPN22 1858 C/T polymorphism from genome wide association studies showing significant p-value (5 × 10−8 < p< 0.05).
| Author, Year | NO. of studies | Comparison | OR (95% CI) | p-Value | Model | Disease | Ethnicity | I2 (%) | Power OR 1.2 | Power OR 1.5 | FPRP Values at Prior Probability | BFDP 0.001 | BFDP 0.000001 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR 1.2 | OR 1.5 | |||||||||||||||
| 0.001 | 0.000001 | 0.001 | 0.000001 | |||||||||||||
| Merkel PA, 2017 [51S] | 3 | T vs. C | 1.36 (1.21–1.53) | 1.86 × 10−7 | - | ANCA | Overall European ancestry | 0.019 | 0.948 | 0.016 | 0.943 | 0.000 | 0.247 | 0.019 | 0.020 | 0.953 |
| Törn C, 2015 [52S] | 3 | T vs. C | 2.42 (1.70–3.44) | 1.01 × 10−6 | - | T1DM vs. Ab- | Caucasian children | 0.000 | 0.004 | 0.948 | 1,000 | 0.180 | 0.995 | 0.000 | 0.601 | 0.999 |
| Serrano A, 2013 | 4 | T vs. C | 1.51 (1.28–1.79) | 2.0 × 10−6 | F | GCA | Caucasian | 0.004 | 0.469 | 0.336 | 0.998 | 0.004 | 0.814 | 0.004 | 0.151 | 0.994 |
| Thompson SD, 2010 [53S] | 3 | Recessive | 1.63 (1.35–1.97) | 3.12 × 10−7 | - | JIA | Germany +Texas +Utah | 0.001 | 0.195 | 0.360 | 0.998 | 0.002 | 0.689 | 0.001 | 0.062 | 0.985 |
GCA, giant cell arteritis; PsA, psoriatic arthritis; JIA, juvenile idiopathic arthritis; RA, rheumatoid arthritis; ANCA, antineutrophil cytoplasmic antibody; GPA, granulomatosis with polyangiitis; MPA, microscopic polyangiitis; PR3, proteinase 3; cANCA, cytoplasmic ANCA; MPO, myeloperoxidase; pANCA, perinuclear ANCA; MG, myasthenia gravis; OR, odds ratio; R, random; FPRP, false-positive report probability; BFDP, Bayesian false discovery probability. Each comparison of genetic associations was regarded as noteworthy when FPRP of <0.2 or BFDP of <0.8 or both are fulfilled and the values were bolded when the results are significant by FPRP or BFDP.