Table 4.
Effect of genotype distribution of studied SNPs for OCT1 gene on glycemic control and on HbA1c level in Jordanian T2DM patients receiving metformin.
| Gene | SNP ID | Genotype | Total | Adequate Glycemic Control | Inadequate Glycemic Control | p-Value * | Mean HbA1c ± SD | p-Value * |
|---|---|---|---|---|---|---|---|---|
| OCT1 | rs1867351 | AA | 138 | 58 | 80 | 0.187 | 7.93 ± 2.06 | 0.136 |
| GA | 65 | 21 | 44 | 8.21 ± 2.04 | ||||
| GG | 7 | 5 | 2 | 6.45 ± 2.33 | ||||
| rs2282143 | CC | 205 | 84 | 121 | 0.153 | 7.98 ± 2.11 | 0.872 | |
| CT | 7 | 1 | 6 | 8.11 ± 1.48 | ||||
| TT | 0 | 0 | 0 | - | ||||
| rs2297374 | CC | 46 | 21 | 25 | 0.285 | 7.76 ± 1.80 | 0.180 | |
| TC | 103 | 43 | 60 | 7.83 ± 2.02 | ||||
| TT | 62 | 20 | 42 | 8.43 ± 2.36 | ||||
| rs461473 | AA | 1 | 1 | 0 | 0.311 | 5.60 | 0.253 | |
| GA | 39 | 13 | 26 | 8.36 ± 2.07 | ||||
| GG | 172 | 71 | 101 | 7.91 ± 2.09 | ||||
| rs4646272 | GG | 1 | 0 | 1 | 0.074 | 10.90 | 0.277 | |
| GT | 15 | 2 | 13 | 8.48 ± 2.28 | ||||
| TT | 195 | 82 | 113 | 7.94 ± 2.07 | ||||
| rs622342 | AA | 88 | 33 | 55 | 0.432 | 8.14 ± 2.20 | 0.277 | |
| CA | 65 | 24 | 41 | 8.16 ± 2.17 | ||||
| CC | 4 | 1 | 3 | 8.10 ± 2.09 | ||||
| rs683369 | CC | 160 | 66 | 94 | 0.146 | 7.83 ± 1.89 | 0.072 | |
| GC | 50 | 17 | 33 | 8.52 ± 2.61 | ||||
| GG | 2 | 2 | 0 | 6.45 ± 0.48 |
* p-value < 0.05 is considered significant.