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. 2019 Mar 6;8(3):318. doi: 10.3390/jcm8030318

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Subgroup analysis by qSOFA score. (a) The mean serum lactate level in metformin users with qSOFA score ≥2 was significantly higher than that in other groups. Significant difference at p < 0.001 compared with nonusers with qSOFA score ≥2 and nonusers with qSOFA score <2; Significant difference at p = 0.001 compared with metformin users with qSOFA score <2. (b) The mean serum lactate level was significantly higher in metformin users with qSOFA score ≥2 than in metformin users with qSOFA score <2 in both nonsurvivors (p = 0.027) and survivors (p = 0.049). No significant difference was found in nonusers with qSOFA score ≥2 compared with nonusers with qSOFA score <2 in both nonsurvivors (p = 0.584) and survivors (p = 0.756).

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