Table 2.
Serum lipids are differentially associated with peripheral leukocyte counts in men from NHANES 1999–2004.
| Lymphocytes | Monocytes | Neutrophils | Eosinophils | Basophils | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GM | 95% CI | GM | 95% CI | GM | 95% CI | GM | 95% CI | GM | 95% CI | ||||||
| Total cholesterol (mg/dL) | |||||||||||||||
| <200 | 1.85 | 1.79 | 1.91 | 0.55 | 0.53 | 0.57 | 3.66 | 3.55 | 3.78 | 1.22 | 1.20 | 1.25 | 1.03 | 1.02 | 1.03 |
| 200 to <240 | 1.84 | 1.78 | 1.90 | 0.54 | 0.52 | 0.56 | 3.79 | 3.63 | 3.96 | 1.23 | 1.20 | 1.26 | 1.03 | 1.02 | 1.04 |
| >240 | 1.93 | 1.84 | 2.03 | 0.54 | 0.51 | 0.56 | 3.81 | 3.62 | 4.00 | 1.23 | 1.21 | 1.25 | 1.03 | 1.03 | 1.04 |
| p-trend | 0.17 | 0.13 | 0.72 | 0.20 | 0.92 | ||||||||||
| LDL-cholesterol (mg/dL) | |||||||||||||||
| <100 | 1.86 | 1.80 | 1.93 | 0.56 | 0.53 | 0.58 | 3.78 | 3.64 | 3.92 | 1.23 | 1.21 | 1.25 | 1.03 | 1.03 | 1.04 |
| 100 to <130 | 1.83 | 1.76 | 1.90 | 0.53 | 0.52 | 0.55 | 3.64 | 3.49 | 3.78 | 1.23 | 1.21 | 1.25 | 1.03 | 1.02 | 1.03 |
| 130 to <160 | 1.85 | 1.78 | 1.93 | 0.54 | 0.52 | 0.57 | 3.73 | 3.59 | 3.88 | 1.22 | 1.19 | 1.25 | 1.03 | 1.02 | 1.03 |
| 160 to <190 | 1.88 | 1.80 | 1.96 | 0.53 | 0.51 | 0.56 | 3.72 | 3.52 | 3.93 | 1.23 | 1.21 | 1.26 | 1.03 | 1.02 | 1.04 |
| >190 | 1.98 | 1.80 | 2.17 | 0.55 | 0.50 | 0.62 | 3.79 | 3.36 | 4.27 | 1.21 | 1.17 | 1.26 | 1.03 | 1.02 | 1.05 |
| p-trend | 0.33 | 0.24 | 0.96 | 0.50 | 0.89 | ||||||||||
| HDL-cholesterol (mg/dL) | |||||||||||||||
| ≥40 | 1.82 | 1.76 | 1.88 | 0.54 | 0.52 | 0.56 | 3.67 | 3.54 | 3.79 | 1.22 | 1.20 | 1.24 | 1.03 | 1.02 | 1.03 |
| <40 | 1.95 | 1.89 | 2.01 | 0.55 | 0.52 | 0.57 | 3.83 | 3.70 | 3.98 | 1.24 | 1.22 | 1.26 | 1.03 | 1.03 | 1.04 |
| p-value | 0.0004 | 0.60 | 0.0114 | 0.05 | 0.0077 | ||||||||||
| Triglyceride (mg/dL) | |||||||||||||||
| <150 | 1.80 | 1.75 | 1.84 | 0.55 | 0.53 | 0.57 | 3.74 | 3.61 | 3.86 | 1.23 | 1.21 | 1.25 | 1.03 | 1.03 | 1.03 |
| 150 to <200 | 1.93 | 1.85 | 2.01 | 0.56 | 0.53 | 0.58 | 3.66 | 3.53 | 3.78 | 1.22 | 1.20 | 1.25 | 1.03 | 1.02 | 1.03 |
| ≥200 | 1.97 | 1.89 | 2.05 | 0.53 | 0.51 | 0.56 | 3.74 | 3.50 | 4.01 | 1.22 | 1.19 | 1.24 | 1.03 | 1.02 | 1.04 |
| p-trend | < 0.0001 | 0.26 | 0.05 | 0.41 | 0.035 | ||||||||||
CI: confidence interval; GM: geometric mean; NHANES: National Health and Nutrition Examination Survey. Clinical ranges for blood lipids levels are presented as mg/dL, and clinical blood leukocyte subsets are presented as geometric means (103 cells/μL). Geometric means and tests for linear trend were adjusted for age, serum cotinine, BMI, waist circumference, race/ethnicity, education, statin use, and survey cycle.