Table 1.
Patient baseline characteristics with regard to TREM-1 rs2234237 genotypes.
| All (n = 649) | AA/AT (n = 104) | TT (n = 545) | p-Value | |
|---|---|---|---|---|
| General | ||||
| Age in years | 63 ± 15 | 64 ± 14 | 63 ± 15 | 0.5392 |
| Sex: Male (%) | 66 | 66 | 66 | 0.9254 |
| BMI | 28 ± 6 | 27 ± 6 | 28 ± 6 | 0.9725 |
| Severity | ||||
| SOFA Day 1 | 9.4 ± 3.9 | 9.0 ± 4.1 | 9.4 ± 3.8 | 0.1421 |
| APACHE II Day 1 | 22 ± 7 | 21 ± 7 | 22 ± 7 | 0.3042 |
| Septic shock (%) | 51 | 57 | 50 | 0.1800 |
| Days in septic shock | 2 ± 3 | 2 ± 3 | 2 ± 3 | 0.1453 |
| Procalcitonin ng/dl Day 1 | 10 ± 29 | 10 ± 26 | 10 ± 30 | 0.8157 |
| Comorbidities (%) | ||||
| Hypertension | 54 | 50 | 55 | 0.3804 |
| History of myocardial infarction | 5 | 1 | 6 | 0.0290 |
| Chronic obstructive pulmonary disease | 15 | 14 | 15 | 0.8703 |
| Bronchial asthma | 3 | 2 | 3 | 0.6275 |
| Renal dysfunction | 10 | 11 | 10 | 0.9262 |
| Noninsulin-dependent diabetes mellitus | 9 | 11 | 8 | 0.4805 |
| Insulin-dependent diabetes mellitus | 10 | 11 | 10 | 0.9712 |
| Chronic liver disease | 6 | 5 | 7 | 0.4898 |
| History of cancer | 15 | 20 | 15 | 0.2387 |
| History of stroke | 6 | 4 | 6 | 0.3410 |
| Dementia | 3 | 4 | 3 | 0.7800 |
| Rheumatoid arthritis | 1 | 0 | 1 | 0.2824 |
| Recent surgical history (%) | 0.0103 | |||
| Elective surgery | 29 | 40 | 27 | |
| Emergency surgery | 53 | 49 | 54 | |
| No surgery | 18 | 11 | 19 | |
| Organ support during observation period (%) | ||||
| Mechanical ventilation | 93 | 92 | 94 | 0.6332 |
| Use of vasopressor | 79 | 78 | 79 | 0.7186 |
| Renal replacement therapy | 21 | 18 | 21 | 0.5133 |
| Organ support on sepsis onset (%) | ||||
| Mechanical ventilation | 86 | 87 | 86 | 0.8200 |
| Use of vasopressor | 67 | 64 | 67 | 0.5878 |
| Renal replacement therapy | 9 | 8 | 9 | 0.6681 |
| Length of stay: | ||||
| LOS ICU | 20 ± 16 | 21 ± 17 | 20 ± 16 | 0.7486 |
Footnote: SOFA, sequential organ failure assessment; APACHE, acute physiology and chronic health evaluation; LOS, Length of stay; ICU, Intensive care unit; BMI, body mass index.